UTHealth Turner Syndrome Research Registry

Part of paid clinical trials in Houston, Texas.

Sponsor
The University of Texas Health Science Center, Houston
Study ID
NCT03185702
Status
Recruiting
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Conditions

  • Turner Syndrome

Eligibility Criteria

Sex
FEMALE
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Research genetic tests — GENETIC
    DNA and tissue-based tests: karyotype, copy number variants, genome-wide association studies and induced pluripotent stem cells

Study Details

The investigators will conduct genetic comparisons between Turner Syndrome (TS) patients with and without Bicuspid Aortic Valve (BAV) to identify causative agents of BAV in people with TS. The investigators will correlate the patterns and prevalence of structural heart defects in TS women with emerging molecular data to identify patients who are at high risk for cardiovascular complications

Key Dates

Start date
Aug 28, 2015
Status verified
Nov 2023
Primary completion
Jan 1, 2030
Completion
Jan 1, 2035

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Patients with Turner Syndrome
    Chromosomal diagnosis and typical features
  • Arm: Unaffected controls
    Normal females and unaffected family members

Primary Outcome Measure

Bicuspid aortic valve and thoracic aortic aneurysm [ Time Frame: 10 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Texas Health Science Center HoustonHoustonTexas77030
Jacqueline Jennings
[email protected]
713-500-6704
Siddharth Prakash, MD, PhD (SUB_INVESTIGATOR)
Michelle Rivera-Davila, MD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Texas Health Science Center Houston· Houston, TX

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