Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery

Part of paid clinical trials in Sewell, New Jersey.

Sponsor
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Study ID
NCT03184038
Status
Recruiting
Apply to this trial

Conditions

  • Metastatic Malignant Neoplasm in the Brain
  • Metastatic Malignant Solid Neoplasm

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Assessment — PROCEDURE
    Undergo assessment of neurocognitive function
  • Stereotactic Radiosurgery — RADIATION
    Undergo SRS
  • Stereotactic Body Radiation Therapy — RADIATION
    Undergo SBRT
  • Quality-of-Life Assessment — OTHER
    Ancillary studies

Study Details

This phase II trial studies the neurological function in patients with multiple brain metastases undergoing stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT). Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Assessment of neurocognitive function may help show that SRS preserves neurological function in patients with multiple brain metastases better than SBRT.

Key Dates

Start date
Feb 21, 2017
Status verified
May 2026
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
90 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Supportive care (SRS/SBRT, neurocognitive testing)
    Patients undergo SRS on day 1 or SBRT for 3 fractions over days 1-7 and undergo neurocognitive testing at baseline, 4, and 12 months after undergoing SRS or SBRT.

Primary Outcome Measure

Neurocognitive function as measured by neurocognitive decline on a battery of tests [ Time Frame: At 4 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Jefferson Health New JerseySewellNew Jersey08080
Karishma Kurowski, MPH
[email protected]
856-341-5199
Tamara LaCouture, MD (PRINCIPAL_INVESTIGATOR)
Sidney Kimmel Cancer Center at Thomas Jefferson UniversityPhiladelphiaPennsylvania19107
Wenyin Shi, MD
(215) 955-6702

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By research site
Jefferson Health New Jersey· Sewell, NJSidney Kimmel Cancer Center at Thomas Jefferson University· Philadelphia, PA

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