Genetic Basis of Melanocytic Nevi

Conditions

• Melanocytic Nevi

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Collecting Nevi — OTHER
  Will be collecting Nevi and completing a DNA analysis, no intervention will be made.

Study Details

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Key Dates

Start date

Jun 26, 2017

Status verified

Sep 2025

Primary completion

Jun 30, 2028

Completion

Jun 30, 2028

Study Design

Enrollment

50 participants (estimated)

Primary Outcome Measure

Genome Wide Mutation Analysis [ Time Frame: Feb 2017 - December 2018 ]

Central Contacts

• Maija Kiuru, MD
  916-734-0591
  [email protected]
• John Robb
  916-551-2636
  [email protected]

Locations (1)

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