Efficacy and Safety of Ibrutinib in Patients With CLL and Other Indolent B-cell Lymphomas Who Are Chronic Hepatitis B Virus Carriers or Occult Hepatitis B Virus Carriers
- Sponsor
- The University of Hong Kong
- Study ID
- NCT02991638
- Phase
- PHASE3
- Status
- Unknown
Conditions
- Chronic Hepatitis B
- Chronic Lymphocytic Leukemia
- Follicular Lymphoma
- Indolent B-cell Lymphomas
- Lymphoma, Small Lymphocytic
- Mantle-Cell Lymphoma
- Waldenstrom's Macroglobulinaemia
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Ibrutinib — DRUGRelapsed / refractory chronic lymphocytic leukemia and Waldenstrom macroglobulinaemia (lymphoplasmacytic lymphoma): 420 mg daily Relapsed / refractory mantle cell lymphoma: 560 mg daily Relapsed / refractory indolent B-cell non-Hodgkin lymphoma: 560 mg daily Treatment is continued until disease progression
Study Details
Efficacy and Safety of ibrutinib in patients with chronic lymphocytic leukemia and other indolent B-cell lymphomas who are chronic hepatitis B virus carriers or occult hepatitis B virus carriers
Key Dates
- Start date
- Nov 1, 2016
- Status verified
- Apr 2018
- Primary completion
- Dec 31, 2020
- Completion
- Jun 30, 2021
Study Design
- Enrollment
- 62 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Other: IbrutinibRelapsed / refractory chronic lymphocytic leukemia and Waldenstrom macroglobulinaemia (lymphoplasmacytic lymphoma): 420 mg daily Relapsed / refractory mantle cell lymphoma: 560 mg daily Relapsed / refractory indolent B-cell non-Hodgkin lymphoma: 560 mg daily Treatment is continued until disease progression
Primary Outcome Measure
Overall response rate (ORR) [ Time Frame: 2 years ]
Central Contacts
- King Hei Lu, MMedSc852-22554361
- Zoe Chan, BNs852-22551654
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