Pharmacogenomics of Warfarin in Hispanics and Latinos

Part of paid clinical trials in Tucson, Arizona.

Sponsor
University of Arizona
Study ID
NCT02972385
Status
Recruiting
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Conditions

  • Hemorrhage
  • Thrombosis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Mouthwash sample — PROCEDURE
    A one time mouthwash sample will be performed.
  • Blood Draw — PROCEDURE
    Patients who are receiving a blood draw during their regular clinical appointment will be asked for a blood sample of 15 milliliters. Genomic DNA will be isolated for genotyping and patient plasma samples will also be stored.

Study Details

Warfarin is a commonly used blood thinner to treat and prevent blood clots. It is important to take the right dose of warfarin because too much can increase the risk of bleeding and too little can increase the risk of blood clots. This is why patients are closely monitored especially when they begin warfarin therapy. When clinicians prescribe warfarin, they have to consider different factors such as patient's age, body size, diet, and other medications that can interact with warfarin. Certain genes have also been found to affect warfarin dose. Individuals have variations in these genes, which can help explain why some patients need higher dose and others require less. These factors have been used to better predict a patient's warfarin dose requirement. However, these predictions were created based on Caucasian populations and they may not be accurate in predicting a safe warfarin dose if a patient is not Caucasian. This study aims to identify new genetic variation that affects warfarin dosing in Hispanic and Latino populations and try to better predict a Hispanic or Latino patient's warfarin dose requirement.

Key Dates

Start date
Sep 30, 2016
Status verified
Jun 2024
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
400 participants (estimated)

Primary Outcome Measure

Stable warfarin dose [ Time Frame: At time of enrollment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Banner University Medical Center - TucsonTucsonArizona85721
Jason H Karnes, PharmD, PhD
[email protected]
520-626-1447

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By research site
Banner University Medical Center - Tucson· Tucson, AZ

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