Prospective Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
Center for International Blood and Marrow Transplant Research
Study ID
NCT02934477
Status
Recruiting
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Conditions

  • Myelofibrosis

Eligibility Criteria

Sex
ALL
Age
55 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Hematopoietic Stem Cell Transplant — OTHER
    This observational study will compare outcomes of prospectively enrolled HCT recipients with outcomes of a cohort of age-matched non-HCT controls.

Study Details

This observational study will compare outcomes of a prospectively-enrolled cohort of Hematopoietic Stem Cell Transplant (HCT) recipients with outcomes of a cohort of age-matched historical non-HCT controls. Patients undergoing alloHCT will receive HCT in a US transplant center and be reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) using well-established CIBMTR report forms and data collection procedures as well as a study-specific supplemental form. Data on the historical non-HCT controls will be collected at 14 US academic centers. These centers will provide data on all consecutive patients with PMF, post-ET MF, or post-PV MF referred to their institutions between 2000 and 2012.

Key Dates

Start date
Nov 30, 2016
Status verified
Aug 2023
Primary completion
Nov 30, 2026
Completion
Oct 31, 2027

Study Design

Enrollment
650 participants (estimated)

Arms

  • Arm: Hematopoietic Stem Cell Transplant (HCT)
    Patients undergoing alloHCT in a US transplant center and reported to the CIBMTR
  • Arm: Non-HCT
    Historical non-transplant controls collected from 14 US academic centers. Centers will provide data on all consecutive patients with PMF, post-ET MF, or post-PV MF referred to their institutions between 2000 and 2012.

Primary Outcome Measure

Compare five year survival [ Time Frame: Five years post transplant ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for International Blood and Marrow Transplant ResearchMinneapolisMinnesota55401
Michael Tierney
[email protected]

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Center for International Blood and Marrow Transplant Research· Minneapolis, MN

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