Safety Study of MELK Inhibitor to Treat Patients With Advanced Breast Cancer and Triple Negative Breast Cancer
Part of paid clinical trials in Norwalk, Connecticut.
- Sponsor
- OncoTherapy Science, Inc.
- Study ID
- NCT02926690
- Phase
- PHASE1
- Status
- Recruiting
Conditions
- Relapsed/Refractory Locally Advanced or Metastatic Breast Cancer and Triple Negative Breast Cancer
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- OTS167PO — DRUGSingle arm, no competitor
Study Details
The purpose of this study is to determine the maximum tolerated dose (MTD) of OTS167 administered via oral capsule (PO) to patients with relapsed/refractory locally advanced or metastatic breast cancer.
Key Dates
- Start date
- May 29, 2017
- Status verified
- Mar 2025
- Primary completion
- Sep 30, 2027
- Completion
- Sep 30, 2027
Study Design
- Enrollment
- 70 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Experimental: OTS167PO
Primary Outcome Measure
MTD [ Time Frame: During Cycle1 after the first administration ]
Locations (8)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Norwalk Hospital | Norwalk | Connecticut | 06856 | - |
| Emory University, Winship Cancer Institute | Atlanta | Georgia | 30322 | Shipra Gandhi, MD, MS (PRINCIPAL_INVESTIGATOR) |
| Kapi'olani Medical Center for Women & Children | Honolulu | Hawaii | 96826 | Naoto Ueno, MD, PhD, FACP (PRINCIPAL_INVESTIGATOR) Jami Fukui, MD (SUB_INVESTIGATOR) |
| Dartmouth Cancer Center/Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | Muhammad Z Afzal, MD (PRINCIPAL_INVESTIGATOR) |
| Memorial Sloan Kettering Cancer Center | New York | New York | 11065 | - |
| Weill Cornell Medicine | NewYork-Presbyterian | New York | New York | 10065 | - |
| MD Anderson Cancer Center | Houston | Texas | 77030 | - |
| Froedtert Hospital & the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Yee Chung Cheng, MD (PRINCIPAL_INVESTIGATOR) |
Find similar trials in Norwalk, CT
By research site
Norwalk Hospital· Norwalk, CTEmory University, Winship Cancer Institute· Atlanta, GAKapi'olani Medical Center for Women & Children· Honolulu, HIDartmouth Cancer Center/Dartmouth-Hitchcock Medical Center· Lebanon, NHMemorial Sloan Kettering Cancer Center· New York, NYWeill Cornell Medicine | NewYork-Presbyterian· New York, NY