A Study of BMS-986207 Given Alone and in Combination With Nivolumab or With Nivolumab and Ipilimumab in Advanced Solid Tumors

Part of paid clinical trials in Hackensack, New Jersey.

Sponsor
Bristol-Myers Squibb
Study ID
NCT02913313
Phase
PHASE1/PHASE2
Status
Completed

Conditions

  • Broad Solid Tumor

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • BMS-986207 — DRUG
    Specified dose on specified days
  • Nivolumab — BIOLOGICAL
    Specified dose on specified days
  • Ipilimumab — BIOLOGICAL
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the safety and effectiveness of experimental medication BMS-986207 by itself, in combination with Nivolumab, and in combination with both nivolumab and ipilimumab in participants with solid cancers that are advanced or have spread.

Key Dates

Start date
Nov 30, 2016
Status verified
Apr 2025
Primary completion
Jan 25, 2024
Completion
Jan 25, 2024

Study Design

Enrollment
101 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Part 1A: Dose Escalation Monotherapy
  • Experimental: Part 1B: Dose Escalation Combination Therapy
  • Experimental: Part 2A: Expansion Monotherapy
  • Experimental: Part 2B: Expansion Combination Therapy
  • Experimental: Part 1C: Triplet Cohort
  • Experimental: Part 2C: Triplet Expansion

Primary Outcome Measure

Number of Participants With Adverse Events [ Time Frame: From first dose (Day 1) untill 100 days after last dose (Up to approximately 27 months) ]

Locations (6)

FacilityCityStateZIPSite coordinators
Local Institution - 0001HackensackNew Jersey07601-
Local Institution - 0003New YorkNew York10032-
Local Institution - 0002PhiladelphiaPennsylvania19111-
Local Institution - 0012PhiladelphiaPennsylvania19104-
Local Institution - 0009PittsburghPennsylvania15213-
Local Institution - 0010Salt Lake CityUtah84112-

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Local Institution - 0001· Hackensack, NJLocal Institution - 0003· New York, NYLocal Institution - 0002· Philadelphia, PALocal Institution - 0012· Philadelphia, PALocal Institution - 0009· Pittsburgh, PALocal Institution - 0010· Salt Lake City, UT