Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS

Conditions

• PANDAS
• PANS
• Pediatric Acute-Onset Neuropsychiatric Syndrome
• Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections

Eligibility Criteria

Sex

ALL

Age

4 Years - 18 Years

Healthy Volunteers

Accepted

Study Details

This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral (developmental) regression, sensory amplification, movement abnormalities, sleep disturbance, and urinary frequency. PANS is thought to be caused by infection, inflammation, or alternate triggers that is associated with a brain response that leads to these symptoms. The purpose of this study is to examine specific neurologic, immunologic, rheumatologic, and genomic, components in children with the acute-onset of psychiatric symptoms. This research may begin to uncover a much larger story of autoimmune processes that are involved in psychiatric disorders of childhood. By better understanding the etiologic components of psychiatric phenomenon, future treatments may be better targeted to underlying causes.

Key Dates

Start date

Mar 31, 2013

Status verified

Oct 2016

Primary completion

Mar 31, 2028

Completion

Mar 31, 2028

Study Design

Enrollment

500 participants (estimated)

Arms

• Arm: PANS group
  500 children, 1-18 years old at onset with a strict diagnosis of PANS/PANDAS will be recruited
• Arm: Health Controls
  100 healthy children age- and gender- matched to the PANS group will be recruited

Primary Outcome Measure

Cerebral blood flow [ Time Frame: Through study completion, up to 12 years ]

Central Contacts

• Joanne Cheung
  [email protected]
• Ellen Spartz

Locations (1)

Find similar trials in Palo Alto, CA

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