The Effects of Bariatric Surgeries on Glucose Metabolism

Part of paid clinical trials in San Antonio, Texas.

Sponsor
The University of Texas Health Science Center at San Antonio
Study ID
NCT02823665
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Gastric Bypass
  • Hypoglycemia After Gastric Bypass
  • Post Bariatric Surgery
  • Sleeve Gastrectomy

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Exendin-(9-39) — DRUG
    A physiological study to evaluate the role of GLP-1 on glucose metabolism and insulin secretin after glucose and protein ingestion.
  • Atropine — DRUG
    A physiological study to evaluate the effect of neural activation on insulin secretion and glucose metabolism.

Study Details

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

Key Dates

Start date
Jul 31, 2015
Status verified
Sep 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Exendin-(9-39)
    To evaluate the role of GLP-1 on glucose metabolism and insulin secretin after glucose and protein ingestion.
  • Experimental: Atropine
    to evaluate the effect of neural activation on insulin secretion and glucose metabolism

Primary Outcome Measure

Insulin levels measured after nutrient ingestion [ Time Frame: Each study in the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure. ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
South Texas Veterans Health Care SystemSan AntonioTexas78229
Marzieh Salehi, MD
[email protected]
210-567-6691
Jennifer Foster, MSN
[email protected]
210-450-8696
Marzieh Salehi, MD (PRINCIPAL_INVESTIGATOR)
Texas Diabetes Institute - University Health SystemSan AntonioTexas78207
Marzieh Salehi, MD
[email protected]
210-567-6691
Jennifer Foster, MSN
[email protected]
210-450-8696
Marzieh Salehi, MD (PRINCIPAL_INVESTIGATOR)

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By research site
South Texas Veterans Health Care System· San Antonio, TXTexas Diabetes Institute - University Health System· San Antonio, TX

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