A Study of Brentuximab Vedotin Combined With Nivolumab for Relapsed or Refractory Hodgkin Lymphoma

Part of paid clinical trials in Duarte, California.

Sponsor
Seagen Inc.
Study ID
NCT02572167
Phase
PHASE1/PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • brentuximab vedotin — DRUG
    1.8 mg/kg by intravenous (IV) infusion for up to 4 cycles
  • nivolumab — DRUG
    3 mg/kg by intravenous (IV) infusion for up to 4 cycles

Study Details

The purpose of this study is to assess the safety profile and antitumor activity of brentuximab vedotin administered in combination with nivolumab in patients with relapsed or refractory Hodgkin lymphoma (HL)

Key Dates

Start date
Oct 31, 2015
Status verified
Oct 2022
Primary completion
Mar 1, 2018
Completion
Oct 21, 2021

Study Design

Enrollment
93 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Brentuximab Vedotin + Nivolumab
    Brentuximab vedotin plus nivolumab

Primary Outcome Measure

Number of Participants With Adverse Events (AEs) [ Time Frame: Up to 28.9 months ]

Locations (13)

FacilityCityStateZIPSite coordinators
City of Hope National Medical CenterDuarteCalifornia91010-3000-
Stanford Cancer CenterStanfordCalifornia94305-
Dana Farber Cancer InstituteBostonMassachusetts02215-
Karmanos Cancer Institute / Wayne State UniversityDetroitMichigan48201-
Mayo Clinic MinnesotaRochesterMinnesota55905-
Washington University School of MedicineSt LouisMissouri63110-
University of Nebraska Medical CenterOmahaNebraska68198-7680-
Hackensack University Medical CenterHackensackNew Jersey07601-
Memorial Sloan Kettering Cancer Center - CommackCommackNew York11725-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10021-
Duke University Medical CenterDurhamNorth Carolina27710-
James Cancer Hospital / Ohio State UniversityColumbusOhio43210-
Charles A. Sammons Cancer Center / Baylor University Medical CenterDallasTexas75246-

Find similar trials in Duarte, CA

By research site
City of Hope National Medical Center· Duarte, CAStanford Cancer Center· Stanford, CADana Farber Cancer Institute· Boston, MAKarmanos Cancer Institute / Wayne State University· Detroit, MIMayo Clinic Minnesota· Rochester, MNWashington University School of Medicine· St Louis, MO

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