Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

Part of paid clinical trials in San Francisco, California.

Sponsor
University of Southern California
Study ID
NCT02434393
Status
Recruiting
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Conditions

  • Late Life Depression (LLD)
  • Major Depression

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of new participants for a period of 30 months. Data from an additional 300 non-depressed subjects will be used from ADNI studies for comparison. Depression history, symptom severity and health information will be collected at the initial visit to determine eligibility. An magnetic resonance imaging (MRI) scan, as well as amyloid (florbetapir) and tau (flortaucipr) positron emission tomography (PET) imaging will be conducted at San Francisco VA. Collection of plasma and serum for biomarkers, clinical assessments and cognitive assessments will be conducted at two time points. Blood samples will also be collected for genetic analysis.

Key Dates

Start date
Mar 4, 2015
Status verified
Nov 2025
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Late Life Depression
    120 participants who meet the criteria for Major Depression or Late Life Depression (LLD)

Primary Outcome Measure

Rate of Change in neuropsychological measures of executive function as measured by the Digit Symbol Substitution Test using total correct. [ Time Frame: 5 years (parent protocol), 5 years (continuation) ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of California, San FranciscoSan FranciscoCalifornia94143
Scott Mackin, Ph.D. (PRINCIPAL_INVESTIGATOR)
Duygu Tosun, Ph.D. (PRINCIPAL_INVESTIGATOR)
University of PittsburghPittsburghPennsylvania15213-

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