Characterization of Hyperpolarized Pyruvate MRI Reproducibility

Part of paid clinical trials in Montvale, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT02421380
Status
Recruiting
Apply to this trial

Conditions

  • Malignant Solid Tumors

Eligibility Criteria

Sex
ALL
Age
21 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • Hyperpolarized Pyruvate — DRUG

Study Details

The purpose of the study is to test a new approach to see if the test results can be reproduced each time the Magnetic resonance imaging (MRI) is done for an individual patient. The study will explore the use of an imaging agent called hyperpolarized \[1-13C\] pyruvate (HP) with MRI scans. (MRI) is a technique that takes pictures of the body's organs using a magnetic field and radiofrequency waves that cannot be felt. In order to accomplish the goal of the study the patient will have two hyperpolarized MRI scans to assess if scans can be reproduced. The hyperpolarized MRI scans will be compared with the pathological results of the surgery to see if the hyperpolarized MRI provides additional information regarding disease metabolism.

Key Dates

Start date
Apr 30, 2015
Status verified
Nov 2025
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
109 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Hyperpolarized Pyruvate MRI Reproducibility
    This is a reproducibility study of hyperpolarized \[1-13C\] pyruvate MRI in patients with solid tumors. A total of 100 patients will be enrolled, 50 of whom will be imaged using 1D MR spectroscopy and the other 50 with 3D imaging sequence.

Primary Outcome Measure

validate HP MRI at MSKCC (are the scans able to be reproduced) [ Time Frame: 1 year ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Bergen (Consent only )MontvaleNew Jersey07645
Kayvan Keshari, PhD
646-888-3631
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Kayvan Keshari, PhD
646-888-3631
Vesselin Miloushev, MD
212-639-3087

Find similar trials in Montvale, NJ

By research site
Memorial Sloan Kettering Bergen (Consent only )· Montvale, NJMemorial Sloan Kettering Cancer Center· New York, NY

Related Studies