Effects of High Altitude on AMPK Activation

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT02391519
Status
Recruiting
Apply to this trial

Conditions

  • IUGR
  • Preeclampsia
  • Pregnancy

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Collection of myometrial, cord blood, and placental tissue samples — PROCEDURE
    We propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA).

Study Details

Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.

Key Dates

Start date
Jan 31, 2016
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
84 participants (estimated)

Arms

  • Arm: High Altitude (3000 m)
    Collection of myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA).
  • Arm: Low Altitude (1600 m)
    Collection of myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA).

Primary Outcome Measure

Changes in Myometrial artery dimensions [ Time Frame: Up to 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado Denver Anschutz Medical CampusAuroraColorado80045
Lorna Moore, PhD (PRINCIPAL_INVESTIGATOR)
Anna Euser, MD (SUB_INVESTIGATOR)
Colleen Julian, PhD (SUB_INVESTIGATOR)

Find similar trials in Aurora, CO

By research site
University of Colorado Denver Anschutz Medical Campus· Aurora, CO

Related Studies