Genomic Predictors of Papillary Microcarcinoma Disease Progression

Conditions

• Papillary Microcarcinoma

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Study Details

The study is being done to answer the following question: What are the specific clinical and molecular features that will help us predict which small thyroid cancers are likely to grow and be problematic? Therefore, the purpose of this study is to identify specific clinical and molecular characteristics that are predictive of tumor progression in small thyroid cancers.

Key Dates

Start date

Dec 31, 2014

Status verified

Mar 2026

Primary completion

Dec 31, 2027

Completion

Dec 31, 2027

Study Design

Enrollment

750 participants (estimated)

Arms

• Arm: Papillary Microcarcinoma
  This clinical trial protocol describes implementation of a prospective observation protocol to standardize data collection and obtain permission to collect samples of PMC tumors in a cohort of PMC patients being followed with active surveillance. This will allow PMC tumors to be accurately classified as either stable or progressive over time and used for comprehensive molecular profiling if surgical removal is required during follow-up

Primary Outcome Measure

estimate the disease progression rate [ Time Frame: 4 years ]

Central Contacts

• Robert Tuttle, MD
  646-888-2716
• Michael Berger, PhD
  646-888-3386

Locations (1)

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