Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis

Part of paid clinical trials in Denver, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT02315729
Status
Recruiting
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Conditions

  • Adolescent Idiopathic Scoliosis

Eligibility Criteria

Sex
FEMALE
Age
10 Years - 13 Years
Healthy Volunteers
Not accepted

Study Details

The purpose of this study is to identify potential markers for curve progression in adolescent idiopathic scoliosis (AIS). Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Clinical criteria and features cannot adequately predict which children, diagnosed with mild disease, will undergo subsequent curve progression requiring intervention. The investigators hypothesize that alterations in specific genetic markers will be correlated with the progression of AIS curves over time. Thus, these markers could be used in the future to develop a reliable, inexpensive and relatively non-invasive cell based diagnostic test to (1) predict spinal curve progression in AIS, (2) select patients likely to benefit from early surgical intervention, and (3) potentially screen for asymptomatic children at risk of developing idiopathic scoliosis.

Key Dates

Start date
Nov 30, 2016
Status verified
Sep 2023
Primary completion
Dec 31, 2025
Completion
Dec 31, 2028

Study Design

Enrollment
380 participants (estimated)

Primary Outcome Measure

Scoliosis Curve Progression [ Time Frame: 3 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Children'S Hospital of ColoradoDenverColorado80045
jiandong hao
[email protected]
303-724-7457

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By research site
Children'S Hospital of Colorado· Denver, CO

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