Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease

Conditions

• Microvascular Coronary Dysfunction

Eligibility Criteria

Sex

FEMALE

Age

18 Years - 60 Years

Healthy Volunteers

Accepted

Interventions

• Handgrip — OTHER
  Subjects will be asked to squeeze and handgrip dynamometer to increase cardiac metabolic demand
• Altitude simulation — OTHER
  Subjects will breathe a lower concentration of oxygen to simulate the effects of altitude.
• Leg exercise — OTHER
  Subjects will perform leg exercise to increase metabolic demand.

Study Details

Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.

Key Dates

Start date

Nov 30, 2014

Status verified

Aug 2023

Primary completion

Dec 31, 2030

Completion

Dec 31, 2030

Study Design

Enrollment

30 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Arms

• Experimental: Women w/microvascular disease
  10 women with microvascular disease
• Experimental: Normal controls
  10 age-matched women with no evidence of microvascular disease
• Experimental: calibration
  10 healthy individuals who will help to synchronize our imaging and stress testing maneuvers.

Primary Outcome Measure

Diastolic function by MRI [ Time Frame: 24 hours ]

Central Contacts

• Barbra Streisand Women's Heart Center
  310-423-9666

Locations (1)

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