OCT Angiography in Wet AMD

Conditions

• Neovascular (Wet) Age-related Macular Degeneration (AMD)

Eligibility Criteria

Sex

ALL

Age

50 Years - 100 Years

Healthy Volunteers

Accepted

Interventions

• Optical Coherence Tomography — DEVICE

Study Details

The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) 2. evaluate patients undergoing treatment for wet AMD 3. determine if reduced flow to the choroid is a risk factor for developing wet AMD.

Key Dates

Start date

Sep 30, 2014

Status verified

Feb 2024

Primary completion

Dec 31, 2026

Completion

Dec 31, 2026

Study Design

Enrollment

160 participants (estimated)

Arms

• Arm: Newly-diagnosed, untreated wet AMD
  This group will be adults newly diagnosed with wet AMD who have not undergone any treatment for the condition. Their data will be gathered only once, prior to treatment.
• Arm: Wet AMD undergoing "as-needed" treatment
  This group will be adults undergoing treatment as-needed for wet AMD. They will be followed monthly over the course of 1 year.
• Arm: High-risk eyes
  This group will be adults with wet AMD in one eye and findings of dry AMD in the other. The eye with dry AMD will be followed every 6 months for 3 years.
• Arm: Wet AMD undergoing a "treat and extend" strategy
  This group will be adults with wet AMD undergoing treatment under the "treat and extend" strategy. (The "treat and extend" strategy increases the intervals between treatments as long as the macula remains dry.) They will be followed over the course of 1 year with extra imaging before extending follow-up intervals.

Primary Outcome Measure

Measure of choroidal neovascular (CNV) vessel area in mm2 [ Time Frame: 1 year ]

Central Contacts

• George Pacheco, COA
  503-494-7398
  [email protected]
• Denny Romfh, OD
  503-494-4351
  [email protected]

Locations (1)

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