Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
University of Chicago
Study ID
NCT02199665
Phase
PHASE1
Status
Completed

Conditions

  • Refractory Multiple Myeloma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • selinexor — DRUG
    Given PO
  • carfilzomib — DRUG
    Given IV
  • dexamethasone — DRUG
    Given PO or IV

Study Details

This phase I trial studies the side effects and best dose of selinexor and carfilzomib when given together with dexamethasone in treating patients with multiple myeloma that has returned or does not respond to treatment. Drugs used in chemotherapy, such as selinexor and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving selinexor, carfilzomib, and dexamethasone may be a better treatment for multiple myeloma.

Key Dates

Start date
Jun 12, 2014
Status verified
Sep 2025
Primary completion
Oct 31, 2025
Completion
Oct 25, 2025

Study Design

Enrollment
52 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Selinexor, carfilzomib, dexamethasone
    Patients receive selinexor PO, carfilzomib IV, and dexamethasone PO QD or IV. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Maximum Tolerated Dose (MTD) of selinexor, carfilzomib, and dexamethasone [ Time Frame: 28 days ]

Locations (5)

FacilityCityStateZIPSite coordinators
Mayo Clinic (AZ)ScottsdaleArizona85259-
University of ChicagoChicagoIllinois60637-
University of Michigan Comprehensive Cancer CenterAnn ArborMichigan48109-
Wayne State University Karmanos Cancer InstituteDetroitMichigan48201-
Mount Sinai Medical CenterNew YorkNew York10029-

Find similar trials in Scottsdale, AZ

By research site
Mayo Clinic (AZ)· Scottsdale, AZUniversity of Chicago· Chicago, ILUniversity of Michigan Comprehensive Cancer Center· Ann Arbor, MIWayne State University Karmanos Cancer Institute· Detroit, MIMount Sinai Medical Center· New York, NY

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