Metabolic Biomarkers in Thoracic Cancers

Conditions

• Lung Cancer

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Imaging Biomarkers — PROCEDURE
  Want to see if using 13C-glucose helps in detecting cancer and deciding on a treatment plan.

Study Details

The purpose of this research study is to develop a method of using magnetic resonance imaging (MRI) to evaluate lung tumors and other thoracic malignancies. An MRI is a scanning device that uses magnets to make images (pictures) of the body. This study is being done to determine what series of reactions (metabolic pathways) pulmonary nodules use as they burn sugar as fuel for growth. The manner in which the tumor burns (metabolizes) sugar for fuel is being investigated by using a natural, slightly modified, sugar solution (13C-glucose) and studying a small sample of the tumor once it is removed at the time of surgery.

Key Dates

Start date

Mar 20, 2013

Status verified

Apr 2026

Primary completion

Dec 31, 2026

Completion

Dec 31, 2027

Study Design

Enrollment

200 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Surgery
  The 13C-glucose solution will be given intravenously. It will be started at about the same time as the start of surgery, according to the study guidelines. The 13C-glucose IV solution will be stopped once the surgeon has removed the tumor tissue.

Primary Outcome Measure

DCE-MRI [ Time Frame: One time - within 5 days of the scheduled surgery ]

Central Contacts

• Ebele Mbanugo, Ed.D, CCRP
  214-648-7097
  [email protected]

Locations (1)

Find similar trials in Dallas, TX

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