Adalimumab Intralesional in Intestinal Strictures of Crohn's Disease Patients
- Sponsor
- Sara Varea
- Study ID
- NCT01986127
- Phase
- PHASE3
- Status
- Terminated
Conditions
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Adalimumab — DRUGsingle intralesional administration during endoscopy process
- placebo — DRUGsingle intralesional administration during endoscopy
Study Details
We study if the administration of intralesional Adalimumab (directly injected in the stricture) associated to endoscopic dilatation has a higher success rate at week 8 compared with placebo in patients with Crohn's disease who had confirmed intestinal stenosis (3 stenosis as maximum)
Key Dates
- Start date
- Feb 14, 2014
- Status verified
- Dec 2018
- Primary completion
- Jun 30, 2018
- Completion
- Jun 30, 2018
Study Design
- Enrollment
- 26 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Adalimumabsingle administration of Adalimumab 80mg diluted in 5ml saline
- Placebo Comparator: saline5 ml of saline
Primary Outcome Measure
Success of endoscopic dilatation [ Time Frame: at week 8 ]
Related Studies
- Autologous Stem Cell Transplantation for Crohn's DiseasePHASE1/PHASE2 · Recruiting · Paul Szabolcs · Pittsburgh, Pennsylvania
- Fecal Microbiome TransplantPHASE1 · Enrolling By Invitation · Judith Kelsen · Philadelphia, Pennsylvania
- Improving the Quality of Care for Adults With Inflammatory Bowel DiseaseEnrolling By Invitation · Dartmouth-Hitchcock Medical Center · Los Angeles, California
- An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With UstekinumabPHASE1/PHASE2 · Recruiting · National Institute of Allergy and Infectious Diseases (NIAID) · Bethesda, Maryland