Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT01849263
Phase
PHASE2
Status
Active Not Recruiting

Conditions

  • Grade 3a Follicular Lymphoma
  • Recurrent Grade 1 Follicular Lymphoma
  • Recurrent Grade 2 Follicular Lymphoma
  • Recurrent Grade 3 Follicular Lymphoma
  • Refractory Follicular Lymphoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Ibrutinib — DRUG
    Given PO
  • Laboratory Biomarker Analysis — OTHER
    Correlative studies

Study Details

This phase II trial studies how well ibrutinib works in treating patients with follicular lymphoma that has come back after a period of improvement or does not respond to treatment. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Key Dates

Start date
Apr 2, 2013
Status verified
Mar 2026
Primary completion
Jun 3, 2016
Completion
Mar 19, 2027

Study Design

Enrollment
41 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (ibrutinib)
    Patients receive ibrutinib PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients with progressive disease at the end of course 2 may continue on therapy until the end of course 5 at the discretion of the treating physician.

Primary Outcome Measure

Overall Response Rate [ Time Frame: Up to 5 years ]

Locations (8)

FacilityCityStateZIPSite coordinators
Mayo Clinic in ArizonaScottsdaleArizona85259-
Mayo Clinic in FloridaJacksonvilleFlorida32224-9980-
Mayo Clinic in RochesterRochesterMinnesota55905-
Metro Minnesota Community Oncology Research ConsortiumSaint Louis ParkMinnesota55416-
Park Nicollet Clinic - Saint Louis ParkSaint Louis ParkMinnesota55416-
Washington University School of MedicineSt LouisMissouri63110-
Fox Chase Cancer CenterPhiladelphiaPennsylvania19111-
University of Wisconsin Carbone Cancer Center - University HospitalMadisonWisconsin53792-

Find similar trials in Scottsdale, AZ

By research site
Mayo Clinic in Arizona· Scottsdale, AZMayo Clinic in Florida· Jacksonville, FLMayo Clinic in Rochester· Rochester, MNMetro Minnesota Community Oncology Research Consortium· Saint Louis Park, MNPark Nicollet Clinic - Saint Louis Park· Saint Louis Park, MNWashington University School of Medicine· St Louis, MO

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