Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT)

Part of paid clinical trials in Newark, Delaware.

Sponsor
Duke University
Study ID
NCT01800968
Phase
PHASE2
Status
Completed

Conditions

  • Acute Heart Failure

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The primary objective is to test the hypothesis that, compared with placebo, therapy with Subcutaneous (SQ) GLP-1 agonist in the post-Acute Heart Failure Syndrome (AHFS) discharge period will be associated with greater clinical stability at six months as assessed by a composite clinical endpoint.

Key Dates

Start date
Apr 30, 2013
Status verified
Feb 2017
Primary completion
Oct 31, 2015
Completion
Oct 31, 2015

Study Design

Enrollment
300 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Liraglutide
    Increasing dose from 0.6mg, 1.2mg to 1.8mg SQ daily.
  • Placebo Comparator: Placebo
    Placebo dose increasing from 0.6mg, 1.2mg to 1.8 mg SQ daily.

Primary Outcome Measure

Global Ranking of Predefined Events [ Time Frame: Randomization to 180 days ]

Locations (25)

FacilityCityStateZIPSite coordinators
Christiana Care Health ServicesNewarkDelaware19718-
Emory University School of MedicineAtlantaGeorgia30322-
Northwestern UniversityChicagoIllinois60611-
Johns Hopkins HospitalBaltimoreMaryland21287-
Brigham and Women's HospitalBostonMassachusetts02115-
Massachusetts General HospitalBostonMassachusetts02114-
Tufts Medical CenterBostonMassachusetts02111-
Boston VA Healtcare SystemWest RoxburyMassachusetts02132-
Mayo ClinicRochesterMinnesota55905-
Saint Louis University HospitalSt LouisMissouri63117-
Washington UniversitySt LouisMissouri63110-
Duke UniversityDurhamNorth Carolina27705-
Southeast Regional Medical CenterLumbertonNorth Carolina28538-
Cleveland ClinicClevelandOhio44195-
Metro Health SystemClevelandOhio44109-
University Hospitals- Case Medical CenterClevelandOhio44106-
Lancaster Heart and Stroke FoundationLancasterPennsylvania17603-
Jefferson Medical CollegePhiladelphiaPennsylvania19107-
Temple University HospitalPhiladelphiaPennsylvania19140-
University of PennsylvainaPhiladelphiaPennsylvania19104-
Michael Debakey VA Medical CenterHoustonTexas77030-
Intermountain Medical CenterMurrayUtah84157-
University of Utah School of MedicineSalt Lake CityUtah84132-
Utah VA Medical CenterSalt Lake CityUtah84132-
The University of Vermont- Fletcher Allen Health CareBurlingtonVermont05401-

Find similar trials in Newark, DE

By research site
Christiana Care Health Services· Newark, DEEmory University School of Medicine· Atlanta, GANorthwestern University· Chicago, ILJohns Hopkins Hospital· Baltimore, MDBrigham and Women's Hospital· Boston, MAMassachusetts General Hospital· Boston, MA

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