In Vivo Real-time Detection of Circulating Melanoma Cells

Part of paid clinical trials in Little Rock, Arkansas.

Sponsor
University of Arkansas
Study ID
NCT01776905
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Study Details

The objective of this clinical trial is to determine whether a Photoacoustic flow cytometry (PAFC)-based prototype device can detect circulating tumor cells (CTCs) in the blood of melanoma patients in vivo, in real time, and do so at detection limits at least one order of magnitude below the detection limits of currently existing ex vivo methods.

Key Dates

Start date
Feb 28, 2013
Status verified
Jul 2025
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
75 participants (estimated)

Arms

  • Arm: Healthy control subjects
    Characterize the baseline PA signals produced by the in vivo PAFC prototype device in healthy volunteers or Develop Standard Curves for the ex vivo CTC assays.
  • Arm: Advanced-Stage Melanoma
    To validate the in vivo PAFC method of melanoma CTC detection, we will use the PAFC-based prototype device to noninvasively determine CTC concentrations in the blood of subjects who have advanced-stage (Stage III or Stage IV)melanoma, and we will also use current ex vivo methods to determine the CTC concentration in samples of blood drawn from the same subjects.
  • Arm: Early-Stage Melanoma
    To determine whether in vivo PAFC can detect melanoma CTCs at concentrations below the detection limits of the ex vivo methods, we will use the PAFC-based prototype device to noninvasively detect CTCs in the blood of subjects who have early-stage (Stages I or II) melanoma, and we will also use current ex vivo methods to detect CTCs in samples of blood drawn from the same subjects.

Primary Outcome Measure

Number of participants that possess circulating tumor cells. [ Time Frame: 14-21 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Arkansas for Medical SciencesLittle RockArkansas72205
Jumin Sunde, MD
[email protected]
501-603-1214
Jumin Sunde (PRINCIPAL_INVESTIGATOR)
Sajjad Bhatti (SUB_INVESTIGATOR)

Find similar trials in Little Rock, AR

By condition
Melanoma
By specialty
OncologySkin cancerDermatology
By research site
University of Arkansas for Medical Sciences· Little Rock, AR

Related Studies