GLP-1 and Microvascular Function in Type 2 Diabetes

Sponsor
Royal Devon and Exeter NHS Foundation Trust
Study ID
NCT01740921
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Liraglutide — DRUG
    Administered once daily
  • diet — OTHER
    reduction of caloric intake to promote weight loss
  • Aspirin — DRUG
    300mg of Aspirin per day

Study Details

Some gut hormones, called incretins, stimulate insulin production in order to control sugar levels but also activate brain centres and signal to stop eating. Current administration of incretin-based therapies mimicking these gut hormones is by subcutaneous (just under the skin) injection and has been routinely available for diabetic patients for more than 4 years. It is an effective treatment for the lowering of blood glucose with an average weight loss of about 3-4kg.Recent evidence, from animal studies and limited human studies, suggests that incretins based treatments may also have beneficial effects on blood vessel function. However, it is not known whether this effect is by direct action on the blood vessel independent of an improvement of latent inflammation which is typically associated with weight loss or an anti-inflammatory effect of the incretin treatment itself. The aim of this study is to determine whether the incretin-based diabetes treatment with the GLP-1 (Glucagon-like peptide 1) analogue Liraglutide (also known as Victoza), which mimics the actions of incretins, improves blood vessel function in individuals with type 2 diabetes. It will determine whether the improvement in blood vessel function is independent of the effect of weight loss and changes in inflammation. This by the study of vascular function before and after 4 months of Victoza treatment in subjects with Type 2 diabetes in comparison with 1) participants randomized to hypo-caloric diet to achieve a similar weight loss than with Victoza and 2) participants randomized to treatment with once daily aspirin. Comprehensive assessment of blood vessel function, body fat distribution and metabolic profile at baseline and at the end of the treatment phase will be combined with assessments of inflammation markers in blood and in fat tissue biopsies.

Key Dates

Start date
Jan 31, 2011
Status verified
Feb 2017
Primary completion
Dec 31, 2015
Completion
Feb 29, 2016

Study Design

Enrollment
39 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Liraglutide
    Liraglutide (Victoza) daily injections
  • Placebo Comparator: diet
    reduction in calorie intake
  • Placebo Comparator: Aspirin
    Aspirin 300mg once daily

Primary Outcome Measure

change of baseline skin maximum hyperaemia at 4 months [ Time Frame: baseline and 4 months ]

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