The Influence of Liraglutide on the Reward Properties of Food: an fMRI Study on Healthy Volunteers
- Sponsor
- Medical University of Vienna
- Study ID
- NCT01695109
- Phase
- PHASE4
- Status
- Completed
Conditions
- Healthy Human Male Subjects
Eligibility Criteria
- Sex
- MALE
- Age
- 18 Years - 40 Years
- Healthy Volunteers
- Accepted
Interventions
- Liraglutide — DRUGsc injections of 0.6 mg Liraglutide daily for three continuous days.
- Placebo — DRUG0.9% NaCl, 0.2 ml
Study Details
Clinical experience has confirmed the anorexic effect of Glucagon-like-peptide 1 (GLP-1) mimetics in comparison to DPP-4 inhibitors. A possible mechanism of this effect might be associated with changes in food choices, as suggested by animal studies. It has been shown that functional magnetic resonance imaging (fMRI) of the brain is a valuable tool in obesity research and can be used to study the response of several brain regions to the visual presentation of preferred in comparison to non preferred food items and to non food items The aim of this study is to search for possible effects of liraglutide in comparison to placebo on 1. food choices and 2. changes in brain function as evidenced by fMRI in healthy volunteers. Findings of this study will help not only to get deeper insight into the mechanism of the anorexic effect of GLP-1 mimetics, but also into the regulation of food choices per se. In the future, it is planned to extend the results of this study in normal weight volunteers to obese diabetic subjects.
Key Dates
- Start date
- Nov 30, 2010
- Status verified
- Sep 2012
- Primary completion
- Feb 29, 2012
- Completion
- Mar 31, 2012
Study Design
- Enrollment
- 16 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- CROSSOVER
- Primary purpose
- BASIC_SCIENCE
Arms
- Placebo Comparator: Placebo
- Active Comparator: Liraglutide
Primary Outcome Measure
Food intake at an ad libitum buffet [ Time Frame: day 4 ]