The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT01202305
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Lymph node biopsy — PROCEDURE
    Inguinal lymph node biopsy

Study Details

HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has found that health is not completely restored in HIV-infected patients, even if they have been taking effective HIV medicines for a long time. This may be due to direct drug-toxicity, continued replication of the virus, and/or inflammation of the body in response to the virus. Therefore, a more complete understanding of how HIV stays in the body is necessary. Recent research has shown that one of the places that HIV can stay in the body is in lymphatic tissues such as lymph nodes (even in patients who have been taking HIV medicines for a long time). In addition, the amount of damage to the lymphatic tissues can predict how the immune system (CD4+ T cell count) will respond to therapy. The investigators therefore propose a study in which lymph nodes from the groin area will be removed, with the goals of: 1) seeing how much HIV is in lymph nodes and 2) seeing how much damage has happened to the lymph node architecture.

Key Dates

Start date
Apr 30, 2011
Status verified
Apr 2026
Primary completion
Apr 30, 2030
Completion
Apr 30, 2030

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: HIV negative
  • Arm: HIV positive

Primary Outcome Measure

HIV persistence [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
San Francisco General HospitalSan FranciscoCalifornia94110
Marian Kerbleski, RN
[email protected]
415-476-4082
Steven Deeks, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in San Francisco, CA

By condition
HIV
By specialty
Infectious disease
By research site
San Francisco General Hospital· San Francisco, CA

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