Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
Part of paid clinical trials in Los Angeles, California.
- Sponsor
- University of Iowa
- Study ID
- NCT01193088
- Status
- Recruiting
Conditions
- Charcot-Marie-Tooth Disease, Type Ia (Disorder)
- HMSN
Eligibility Criteria
- Sex
- ALL
- Age
- N/A - N/A
- Healthy Volunteers
- Accepted
Study Details
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
Key Dates
- Start date
- May 31, 2010
- Status verified
- Sep 2025
- Primary completion
- Dec 31, 2026
- Completion
- Dec 31, 2026
Study Design
- Enrollment
- 1,050 participants (estimated)
Arms
- Arm: CMT1AFamilies/people with genetically defined CMT1A
- Arm: Genetically undefined CMTFamilies/people with genetically undefined CMT with common causes ruled out.
Primary Outcome Measure
Charcot Marie Tooth disease type 1A (CMT1A) gene modifiers [ Time Frame: once ]
Central Contacts
- Tiffany Grider, MS, CGC319-384-6362
- Nicole Kressin, MS, CGC319-384-6362
Locations (17)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Robert Baloh, MD, PhD (PRINCIPAL_INVESTIGATOR) Richard A Lewis, MD (PRINCIPAL_INVESTIGATOR) |
| Stanford University | Palo Alto | California | 94304 | John Day, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| University of Colorado Hospital | Aurora | Colorado | 80045 | Vera Fridman, MD (PRINCIPAL_INVESTIGATOR) |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | Gyula Acsadi, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| University of Miami | Miami | Florida | 33136 | Stephan Zuchner, MD, PhD (PRINCIPAL_INVESTIGATOR) Mario Saporta, MD, PhD, MBA (PRINCIPAL_INVESTIGATOR) |
| University of Iowa | Iowa City | Iowa | 52242 | Michael E Shy, MD (PRINCIPAL_INVESTIGATOR) |
| Johns Hopkins University | Baltimore | Maryland | 21205 | Bipasha Mukherjee-Clavin, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| Harvard/Massachusetts General Hospital | Boston | Massachusetts | 02114 | Reza Seyedsadjadi, MD (PRINCIPAL_INVESTIGATOR) |
| University of Michigan | Ann Arbor | Michigan | 48109 | Brett McCray, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| University of Minnesota | Maple Grove | Minnesota | 55369 | David Walk, MD (PRINCIPAL_INVESTIGATOR) |
| University of Rochester | Rochester | New York | 14642 | David Herrmann, MD (PRINCIPAL_INVESTIGATOR) |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | Rebecca Traub, MD (PRINCIPAL_INVESTIGATOR) |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | Sabrina Yum, MD (PRINCIPAL_INVESTIGATOR) Tim Estilow (SUB_INVESTIGATOR) |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Pooja Patel Steven Scherer, MD (PRINCIPAL_INVESTIGATOR) |
| St. Jude Children's Research Hospital | Memphis | Tennessee | 38105 | Richard Finkel, MD (PRINCIPAL_INVESTIGATOR) Joshua Burns, PhD (PRINCIPAL_INVESTIGATOR) |
| Houston Methodist Hospital | Houston | Texas | 77030 | Jun Li, MD, PhD (PRINCIPAL_INVESTIGATOR) |
| Seattle Children's Hospital | Seattle | Washington | 98105 | Seth Perlman, MD (PRINCIPAL_INVESTIGATOR) |