Abundance and Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University
Study ID
NCT00983463
Status
Enrolling By Invitation

Conditions

  • Nonalcoholic Fatty Liver Disease

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Study Details

Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in the United States. The incidence of NAFLD is very similar to that of obesity, type 2 diabetes, and the metabolic syndrome. The investigators hypothesize that there may be a relationship between over-nutrition, decreased physical activity and the development of fatty liver. The purpose of this study is to identify the types of fats and proteins, and the quantity of each, that are associated with increased severity of NAFLD.

Key Dates

Start date
Oct 31, 2009
Status verified
Dec 2025
Primary completion
Nov 30, 2026
Completion
Nov 30, 2026

Study Design

Enrollment
45 participants (estimated)

Arms

  • Arm: Obese, bariatric surgery, liver biopsy
    Obese subjects approved and scheduled for bariatric surgery at Vanderbilt University Medical Center
  • Arm: Normal BMI, abdominal surgery, liver biopsy
    Normal weight subjects having elective abdominal surgery at Vanderbilt University Medical Center.
  • Arm: Liver transplantation donors and recipients
    All livers made available for implantation or explantation will be eligible.

Primary Outcome Measure

To identify and relatively quantify, using high performance liquid chromatography electrospray ionization mass spectrometry, select lipids and proteins present in human liver biopsies. [ Time Frame: 2 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37232-

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By research site
Vanderbilt University Medical Center· Nashville, TN

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