Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

Conditions

• Dermatologic Diseases

Eligibility Criteria

Sex

ALL

Age

16 Years - N/A

Healthy Volunteers

Accepted

Interventions

• skin tissue sample — OTHER
  skin tissue sample

Study Details

The researchers believe that pro-angiogenic factors are upregulated in a wide range of dermatologic diseases, including port wine stains, hemangiomas, angiofibromas, Kaposi's sarcoma, angiosarcoma, scars, rosacea, and psoriasis. Select specimens may undergo genetic analysis to investigate underlying molecular pathways associated with dysregulated angiogenesis in cutaneous disease. Biospecimens, either previously obtained or newly collected from dermatologic conditions, will be analyzed for angiogenic markers. Discarded skin tissue from surgical or biopsy procedures may also be used, including both diseased and non-diseased tissue from the same donor. Some specimens may also undergo genetic analysis to investigate underlying molecular pathways. De-identified data such as age, sex, race, cause of death, lesion location, and description will be recorded. Currently, specimens are limited to clinically diagnosed lesions not typically biopsied, or lesions already confirmed by prior biopsy.

Key Dates

Start date

Nov 30, 2008

Status verified

Apr 2026

Primary completion

Dec 31, 2028

Completion

Dec 31, 2028

Study Design

Enrollment

85 participants (estimated)

Arms

• Arm: dermatologic diseases
  skin tissue sample

Primary Outcome Measure

Factors in dermatologic diseases. [ Time Frame: up to 4 weeks ]

Central Contacts

• Hanna Kim
  949-824-2251
  [email protected]

Locations (2)

Find similar trials in Irvine, CA