Docetaxel (Taxotere), Vinorelbine, and Bevacizumab, as Adjuvant Chemotherapy for Patients With Resected Stage I-III Non-small Cell Lung Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT00675597
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bevacizumab (Avastin), Taxotere (Docetaxel), Vinorelbine Tartrate (Navelbine) — DRUG
    Patients will be treated as follows: vinorelbine (45 mg/m2) + docetaxel (45 mg/m2) intravenously on day 1, followed by pegylated filgrastim 6mg subcutaneously on day 2, delivered every 2 weeks for 8 doses total. Patients who have already received one cycle of cisplatin-based adjuvant chemotherapy need only complete 3 cycles of vinorelbine+docetaxel for a total of 4 cycles of adjuvant chemotherapy. Patients who require post-operative radiation therapy (PORT) will begin PORT after completion of vinorelbine + docetaxel.

Study Details

The purpose of this study is to determine whether a combination of the drugs docetaxel (Taxotere ® ), plus vinorelbine (Navelbine ® ), will result in fewer side effects than cisplatin chemotherapy, thereby improving delivery of chemotherapy in patients. Another purpose of this study is to determine whether a third drug, bevacizumab (Avastin®), may be delivered safely with docetaxel plus vinorelbine in patients who are eligible to receive bevacizumab.

Key Dates

Start date
May 31, 2008
Status verified
Oct 2015
Primary completion
Feb 29, 2012
Completion
Feb 29, 2012

Study Design

Enrollment
25 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: 1
    Docetaxel (Taxotere), Vinorelbine, and Bevacizumab, as Adjuvant Chemotherapy for Patients with Resected Stage I-III Non-small Cell Lung Cancer

Primary Outcome Measure

To Measure the Number of Cycles [ Time Frame: 2 years ]

Locations (5)

FacilityCityStateZIPSite coordinators
Memorial Sloan-Kettering at Basking RidgeBasking RidgeNew Jersey07920-
Memorial Sloan-Kettering Cancer Center @ SuffolkCommackNew York11725-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
Memorial Sloan-Kettering at Mercy Medical CenterRockville CentreNew York--
Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital CenterSleepy HollowNew York10591-

Find similar trials in Basking Ridge, NJ

By condition
Lung cancer
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OncologyLung oncologyLung disease
By research site
Memorial Sloan-Kettering at Basking Ridge· Basking Ridge, NJMemorial Sloan-Kettering Cancer Center @ Suffolk· Commack, NYMemorial Sloan Kettering Cancer Center· New York, NYMemorial Sloan-Kettering at Mercy Medical Center· Rockville Centre, NYMemorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center· Sleepy Hollow, NY

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