Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer
- Sponsor
- Cancer Research UK
- Study ID
- NCT00664781
- Phase
- PHASE2
- Status
- Completed
Conditions
- Breast Cancer
- Ovarian Cancer
- brca1 Mutation Carrier
- brca2 Mutation Carrier
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- rucaparib (CO-338; formally AG-014699 or PF-01367338) — DRUG
- protein expression analysis — GENETIC
- western blotting — GENETIC
- immunohistochemistry staining method — OTHER
- liquid chromatography — OTHER
- mass spectrometry — OTHER
- pharmacological study — OTHER
Study Details
RATIONALE: rucaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying the side effects and best dose of rucaparib and to see how well it works in treating patients with locally advanced or metastatic breast cancer or advanced ovarian cancer.
Key Dates
- Start date
- Dec 31, 2007
- Status verified
- May 2016
- Primary completion
- Jan 31, 2015
- Completion
- Jan 31, 2015
Study Design
- Enrollment
- 78 participants (actual)
- Primary purpose
- TREATMENT
Primary Outcome Measure
Assessment of antitumor activity according to RECIST using tumor size measured clinically or radiologically with CT scan, MRI, plain x-ray, or other imaging techniques
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- Harvesting Cells for Experimental Cancer TreatmentsEnrolling By Invitation · National Cancer Institute (NCI) · Bethesda, Maryland
- High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast CancerRecruiting · Carol Fabian, MD · Kansas City, Kansas