Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers

Part of paid clinical trials in Stanford, California.

Sponsor
Stanford University
Study ID
NCT00568490
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Tumor biopsy — PROCEDURE
    For patients who undergo tumor biopsy or resection at Stanford, approximately 500 mg of the tumor will be removed from the resection specimen
  • Phlebotomy — PROCEDURE
    Blood draw (approximately 20 cc) prior to any anticancer therapy Weekly blood draw (approximately 20cc) only for patients who are undergoing radiation treatment at Stanford University

Study Details

The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread and enhance tumor resistance to the standard treatment of radiation and chemotherapy in head and neck and lung cancers. We have recently identified several proteins or markers in the blood and in tumors (including osteopontin, lysyl oxidase, macrophage inhibiting factor and proteomic technology) in the laboratory that may be able to identify tumors with low oxygen levels or more aggressive behaving tumors.

Key Dates

Start date
Sep 1, 1998
Status verified
Jun 2025
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
200 participants (estimated)

Primary Outcome Measure

Identification of Secreted Markers for Tumor Hypoxia through tissue collection [ Time Frame: before therapy, weekly during therapy ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford University School of MedicineStanfordCalifornia94305
Eyiwunmi Laseinde
[email protected]
Cancer Clinical Trials Office
(650) 498-7061
Quynh-Thu Le (PRINCIPAL_INVESTIGATOR)
Amato Giaccia (SUB_INVESTIGATOR)
Richard L Goode (SUB_INVESTIGATOR)
Harlan Pinto (SUB_INVESTIGATOR)
Dr. Billy W. Loo Jr. M.D. Ph.D. (SUB_INVESTIGATOR)

Find similar trials in Stanford, CA

By condition
Head and neck cancerLung cancer
By specialty
OncologyENTLung oncologyLung disease
By research site
Stanford University School of Medicine· Stanford, CA

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