Targeted Intra-Operative Radiotherapy for the Management of Ductal Carcinoma In-Situ of the Breast

Part of paid clinical trials in Los Angeles, California.

Sponsor: University of Southern California
Study ID: NCT00556907
Status: Terminated

Conditions

Breast Cancer

Eligibility Criteria

Sex: FEMALE
Age: 40 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Intraoperative radiotherapy — RADIATION
20Gy to surface of tumor bed and 5Gy at depth of 1cm from surface of tumor bed
Intraoperative radiotherapy — DEVICE
20gy to tumor bed, 5gy at depth of 1cm from surface of tumor bed

Study Details

We hypothesize that the combination of mammography and CE-MRI will improve the surgeon and radiologist's ability to define extent of disease prior to surgical resection, improve the odds of obtaining clear surgical margins, and increase the efficacy of IORT delivered immediately after initial surgical resection. In this investigation, we will determine whether or not patients deemed eligible for 'immediate" IORT based on mammography and CE-MRI can be successfully treated without the need for re-excision or additional radiotherapy due to inadequate surgical margins.