Chemotherapy and Internal Radiation in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Part of paid clinical trials in Goshen, Indiana.

Sponsor
Goshen Health System
Study ID
NCT00408551
Phase
PHASE2
Status
Unknown

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • floxuridine — DRUG
    Given IV
  • fluorouracil — DRUG
    Given IV
  • irinotecan hydrochloride — DRUG
    Given IV
  • leucovorin calcium — DRUG
    Given IV
  • oxaliplatin — DRUG
    Given IV

Study Details

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. Giving chemotherapy together with internal radiation may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving chemotherapy together with internal radiation works in treating patients with colorectal cancer that has spread to the liver.

Key Dates

Start date
Nov 30, 2005
Status verified
Jun 2009
Primary completion
Jun 30, 2009

Study Design

Enrollment
20 participants (estimated)
Primary purpose
TREATMENT

Arms

  • Experimental: FOLFOX6
    Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1. Patients also receive fluorouracil IV continously over 46 hours beginning on day 1.
  • Experimental: FOLFIRI
    Patients receive irinotecan hydrochloride IV over 1 hour and leucovorin calcium IV over 2 hours on day 1. Patients also receive fluorouracil IV continuously over 46 hours beginning on day 1.
  • Experimental: FUDR
    Patients receive floxuridine IV continuously on days 1-14.

Primary Outcome Measure

Tumor response as measured by carcinoembryonic antigen (CEA) level, RECIST criteria, and positron emission tomography (PET) scan

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Cancer Care at Goshen General HospitalGoshenIndiana46526
Clinical Trials Office - Center for Cancer Care at Goshen Gene
574-535-2858

Find similar trials in Goshen, IN

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
Center for Cancer Care at Goshen General Hospital· Goshen, IN

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