Ziv-aflibercept in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gynecologic Soft Tissue Sarcoma

Part of paid clinical trials in Duarte, California.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00390234
Phase
PHASE2
Status
Completed

Conditions

  • Fallopian Tube Cancer
  • Female Reproductive Cancer
  • Ovarian Carcinosarcoma
  • Ovarian Sarcoma
  • Recurrent Ovarian Epithelial Cancer
  • Recurrent Uterine Sarcoma
  • Stage III Ovarian Epithelial Cancer
  • Stage III Uterine Sarcoma
  • Stage IV Ovarian Epithelial Cancer
  • Stage IV Uterine Sarcoma
  • Uterine Carcinosarcoma
  • Uterine Leiomyosarcoma

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

This phase II trial is studying how well ziv-aflibercept works in treating patients with locally advanced, unresectable or metastatic gynecologic soft tissue sarcoma. Ziv-aflibercept may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Key Dates

Start date
Sep 30, 2006
Status verified
May 2013
Primary completion
Sep 30, 2011
Completion
Aug 31, 2013

Study Design

Enrollment
63 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (ziv-aflibercept)
    Patients receive ziv-aflibercept IV over 1 hour on day 1. Treatment repeats every 14 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Objective Response Rate, Evaluated According to the RECIST Criteria [ Time Frame: Up to 3 years ]

Locations (8)

FacilityCityStateZIPSite coordinators
City of HopeDuarteCalifornia91010-
University of Southern CaliforniaLos AngelesCalifornia90033-0804-
UC Davis Comprehensive Cancer CenterSacramentoCalifornia95817-
University of Chicago Comprehensive Cancer CenterChicagoIllinois60637-1470-
Evanston CCOP-NorthShore University HealthSystemEvanstonIllinois60201-
Peoria Gynecologic OncologyPeoriaIllinois61603-
University of Michigan University HospitalAnn ArborMichigan48109-
Fox Chase Cancer CenterRockledgePennsylvania19046-

Find similar trials in Duarte, CA

By research site
City of Hope· Duarte, CAUniversity of Southern California· Los Angeles, CAUC Davis Comprehensive Cancer Center· Sacramento, CAUniversity of Chicago Comprehensive Cancer Center· Chicago, ILEvanston CCOP-NorthShore University HealthSystem· Evanston, ILPeoria Gynecologic Oncology· Peoria, IL

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