Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT00243776
Status
Recruiting
Apply to this trial

Conditions

  • Congenital Heart Disease
  • Tetralogy of Fallot

Eligibility Criteria

Sex
ALL
Age
N/A - 20 Years
Healthy Volunteers
Not accepted

Study Details

The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigators hypothesize that infant hearts have different regulation of calcium entry than adult hearts. The study team also wants to study combinations of 3D cardiac spheres with multiple environmental cues that can improve functional and metabolic maturation of Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and generate a more clinically relevant cell model.

Key Dates

Start date
Apr 30, 2005
Status verified
May 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
600 participants (estimated)

Arms

  • Arm: Cardiac Tissue
    Cardiac tissue and cells will be obtained from participants undergoing cardiac surgical repair

Primary Outcome Measure

Calcium Current Measures [ Time Frame: Duration of Study (Up to 13 Years) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Emory University School of MedicineAtlantaGeorgia30322
Mary B Wagner, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Atlanta, GA

By research site
Emory University School of Medicine· Atlanta, GA

Related Studies