The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.

Part of paid clinical trials in New York, New York.

Sponsor
Rockefeller University
Study ID
NCT00230165
Status
Recruiting
Apply to this trial

Conditions

  • Glanzmann Thrombasthenia

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Study Details

Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with red blood cell disorders (such as sickle cell disease), white blood cell disorders, and disorders of the blood clotting factors found in plasma. Blood platelets are small cell fragments that help people stop bleeding after blood vessels are damaged. Some individuals have abnormalities in their blood platelets that result in them not functioning properly. One such disorder is Glanzmann thrombasthenia. Most such patients have a bleeding disorder characterized by nosebleeds, gum bleeding, easy bruising (black and blue marks), heavy menstrual periods in women, and excessive bleeding after surgery or trauma. Our laboratory performs advanced tests of platelet function and platelet biochemistry. If we find evidence that a genetic disorder may be responsible, we analyze the genetic material (DNA and RNA) from the volunteer, and when possible, close family members to identify the precise defect.

Key Dates

Start date
Sep 30, 2005
Status verified
Oct 2025
Primary completion
Jun 30, 2030
Completion
Jun 30, 2030

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Normal
    Normal, healthy volunteers 18 years of age or older of either sex and any ethnic background
  • Arm: Glanzmann thrombasthenia
    Patients with Glanzmann thrombasthenia or their relatives, inherited qualitative and/or quantitative platelet disorders, inherited disorders of white blood cells, inherited disorders of coagulation

Primary Outcome Measure

Platelet aggregation [ Time Frame: minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Rockefeller University HospitalNew YorkNew York10021
Recruitment Specialist
[email protected]
800-782-2737
Barry Coller, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Rockefeller University Hospital· New York, NY

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