N2003-01: Irinotecan, Temozolomide, and Cefixime in Treating Young Patients With Recurrent or Resistant Neuroblastoma

Part of paid clinical trials in Los Angeles, California.

Sponsor
New Approaches to Neuroblastoma Therapy Consortium
Study ID
NCT00093353
Phase
PHASE1
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
1 Year - 30 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

RATIONALE: Drugs used in chemotherapy, such as irinotecan and temozolomide, work in different ways to stop tumor cells from dividing so they stop growing or die. Temozolomide may help irinotecan kill more tumor cells by making them more sensitive to the drug. Cefixime may be effective in preventing diarrhea that is caused by treatment with irinotecan. PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan when given together with temozolomide and cefixime in treating young patients with recurrent or resistant neuroblastoma.

Key Dates

Start date
May 31, 2004
Status verified
May 2009
Primary completion
Jul 31, 2006

Study Design

Enrollment
30 participants (estimated)
Primary purpose
TREATMENT

Locations (13)

FacilityCityStateZIPSite coordinators
Children's Hospital Los AngelesLos AngelesCalifornia90027-0700-
Lucile Packard Children's Hospital at Stanford University Medical CenterPalo AltoCalifornia94304-
UCSF Comprehensive Cancer CenterSan FranciscoCalifornia94143-
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston CampusAtlantaGeorgia30322-
Children's Memorial Hospital - ChicagoChicagoIllinois60614-
Indiana University Cancer CenterIndianapolisIndiana46202-5289-
Children's Hospital BostonBostonMassachusetts02115-
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer InstituteBostonMassachusetts02115-
University of Michigan Comprehensive Cancer CenterAnn ArborMichigan48109-0718-
Cincinnati Children's Hospital Medical CenterCincinnatiOhio45229-3039-
Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104-
Texas Children's Cancer Center and Hematology Service at Texas Children's HospitalHoustonTexas77030-2399-
Children's Hospital and Regional Medical Center - SeattleSeattleWashington98105-

Find similar trials in Los Angeles, CA

By condition
Neuroblastoma
By specialty
OncologyPediatric oncology
By research site
Children's Hospital Los Angeles· Los Angeles, CALucile Packard Children's Hospital at Stanford University Medical Center· Palo Alto, CAUCSF Comprehensive Cancer Center· San Francisco, CAAFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus· Atlanta, GAChildren's Memorial Hospital - Chicago· Chicago, ILIndiana University Cancer Center· Indianapolis, IN

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