Irinotecan and Docetaxel in Treating Patients With Refractory Metastatic Breast Cancer

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Alliance for Clinical Trials in Oncology
Study ID
NCT00079118
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 120 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

RATIONALE: Drugs used in chemotherapy, such as irinotecan and docetaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving irinotecan together with docetaxel works in treating patients with refractory metastatic breast cancer.

Key Dates

Start date
Apr 30, 2004
Status verified
Dec 2016
Primary completion
Feb 28, 2007
Completion
Dec 31, 2010

Study Design

Enrollment
70 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: docetaxel + irinotecan
    Patients receive docetaxel IV over 1 hour followed by irinotecan IV over 1 hour on days 1 and 8. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients who achieve a complete response (CR) receive 2 additional courses beyond CR. Patients are followed every 2 months until disease progression and then every 6 months thereafter.

Primary Outcome Measure

Confirmed tumor response as measured by RECIST criteria [ Time Frame: Up to 5 years ]

Locations (162)

FacilityCityStateZIPSite coordinators
Mayo Clinic ScottsdaleScottsdaleArizona85259-5499-
Mayo Clinic - JacksonvilleJacksonvilleFlorida32224-
Rush-Copley Cancer Care CenterAuroraIllinois60507-
St. Joseph Medical CenterBloomingtonIllinois61701-
Graham HospitalCantonIllinois61520-
Memorial HospitalCarthageIllinois62321-
Eureka Community HospitalEurekaIllinois61530-
Galesburg ClinicGalesburgIllinois61401-
Galesburg Cottage HospitalGalesburgIllinois61401-
Mason District HospitalHavanaIllinois62644-
Hopedale Medical ComplexHopedaleIllinois61747-
Joliet Oncology-Hematology Associates, Limited - WestJolietIllinois60435-
Kewanee HospitalKewaneeIllinois61443-
McDonough District HospitalMacombIllinois61455-
BroMenn Regional Medical CenterNormalIllinois61761-
Community Cancer CenterNormalIllinois61761-
Community Hospital of OttawaOttawaIllinois61350-
Oncology Hematology Associates of Central Illinois, PC - OttawaOttawaIllinois61350-
Cancer Treatment Center at Pekin HospitalPekinIllinois61554-
CCOP - Illinois Oncology Research AssociationPeoriaIllinois61615-
Methodist Medical Center of IllinoisPeoriaIllinois61636-
Oncology Hematology Associates of Central Illinois, PC - PeoriaPeoriaIllinois61615-
OSF St. Francis Medical CenterPeoriaIllinois61637-
Proctor HospitalPeoriaIllinois61614-
Illinois Valley Community HospitalPeruIllinois61354-
St. Margaret's HospitalSpring ValleyIllinois61362-
Carle Cancer Center at Carle Foundation HospitalUrbanaIllinois61801-
CCOP - Carle Cancer CenterUrbanaIllinois61801-
St. Francis Hospital and Health Centers - Beech Grove CampusBeech GroveIndiana46107-
Saint Anthony Memorial Health CentersMichigan CityIndiana46360-
Reid Hospital & Health Care Services, IncorporatedRichmondIndiana47374-
McFarland Clinic, PCAmesIowa50010-
Cedar Rapids Oncology AssociatesCedar RapidsIowa52403-
Mercy Regional Cancer Center at Mercy Medical CenterCedar RapidsIowa52403-
St. Luke's HospitalCedar RapidsIowa52402-
CCOP - Iowa Oncology Research AssociationDes MoinesIowa50309-
John Stoddard Cancer Center at Iowa Lutheran HospitalDes MoinesIowa50316-2301-
John Stoddard Cancer Center at Iowa Methodist Medical CenterDes MoinesIowa50309-
Medical Oncology and Hematology Associates at John Stoddard Cancer CenterDes MoinesIowa50309-
Medical Oncology and Hematology Associates at Mercy Cancer CenterDes MoinesIowa50314-
Mercy Cancer Center at Mercy Medical Center - Des MoinesDes MoinesIowa50314-
Mercy Capitol HospitalDes MoinesIowa50307-
Ottumwa Regional Health Center Cancer CenterOttumwaIowa52501-
Mercy Medical Center - Sioux CitySioux CityIowa51104-
Siouxland Hematology-Oncology Associates, LLPSioux CityIowa51101-
Siouxland Regional Cancer CenterSioux CityIowa51101-
St. Luke's Regional Medical CenterSioux CityIowa51104-
Medical Oncology and Hematology Associates - West Des MoinesWest Des MoinesIowa50266-
Cancer Center of Kansas, PA - ChanuteChanuteKansas66720-
Cancer Center of Kansas, PA - Dodge CityDodge CityKansas67801-
Cancer Center of Kansas, PA - El DoradoEl DoradoKansas67042-
Cancer Center of Kansas, PA - KingmanKingmanKansas67068-
Southwest Medical CenterLiberalKansas67901-
Cancer Center of Kansas, PA - NewtonNewtonKansas67114-
Cancer Center of Kansas, PA - ParsonsParsonsKansas67357-
Cancer Center of Kansas, PA - PrattPrattKansas67124-
Cancer Center of Kansas, PA - SalinaSalinaKansas67042-
Cancer Center of Kansas, PA - WellingtonWellingtonKansas67152-
Associates in Womens Health, PA - North ReviewWichitaKansas67203-
Cancer Center of Kansas, PA - Medical Arts TowerWichitaKansas67208-
Cancer Center of Kansas, PA - WichitaWichitaKansas67214-
CCOP - WichitaWichitaKansas67214-
Via Christi Cancer Center at Via Christi Regional Medical CenterWichitaKansas67214-
Cancer Center of Kansas, PA - WinfieldWinfieldKansas67156-
Hickman Cancer Center at Bixby Medical CenterAdrianMichigan49221-
CCOP - Michigan Cancer Research ConsortiumAnn ArborMichigan48106-
St. Joseph Mercy Cancer Center at St. Joseph Mercy HospitalAnn ArborMichigan48106-0995-
Oakwood Cancer Center at Oakwood Hospital and Medical CenterDearbornMichigan48123-2500-
Genesys Hurley Cancer InstituteFlintMichigan48503-
Hurley Medical CenterFlintMichigan48503-
Van Elslander Cancer Center at St. John Hospital and Medical CenterGrosse Pointe WoodsMichigan48236-
Foote HospitalJacksonMichigan49201-
Haematology-Oncology Associates of Ohio and Michigan, PCLambertvilleMichigan48144-
Sparrow Regional Cancer CenterLansingMichigan48909-
Community Cancer Center of MonroeMonroeMichigan48162-
Mercy Memorial Hospital SystemMonroeMichigan48162-
Seton Cancer Institute - SaginawSaginawMichigan48601-
St. John Macomb HospitalWarrenMichigan48093-
-AlexandriaMinnesota56308-
MeritCare Clinic - BemidjiBemidjiMinnesota56601-
Brainerd Medical CenterBrainerdMinnesota56401-
St. Joseph's Medical CenterBrainerdMinnesota56401-
Fairview Ridges HospitalBurnsvilleMinnesota55337-
Mercy and Unity Cancer Center at Mercy HospitalCoon RapidsMinnesota55433-
CCOP - DuluthDuluthMinnesota55805-
Miller-Dwan Medical CenterDuluthMinnesota55805-
St. Mary's - Duluth Clinic Cancer CenterDuluthMinnesota55805-
Fairview Southdale HospitalEdinaMinnesota55435-
-Fergus FallsMinnesota56537-
Mercy and Unity Cancer Center at Unity HospitalFridleyMinnesota55432-
Hutchinson Area Health CareHutchinsonMinnesota55350-
Meeker County Memorial HospitalLichfieldMinnesota55355-
Immanuel St. Joseph's ClinicMankatoMinnesota56002-
HealthEast Cancer Care at St. John's HospitalMaplewoodMinnesota55109-
Minnesota Oncology Hematology, PA at Maplewood Cancer CenterMaplewoodMinnesota55109-
Hennepin County Medical Center - MinneapolisMinneapolisMinnesota55415-
Virginia Piper Cancer Institute at Abbott-Northwestern HospitalMinneapolisMinnesota55407-
Chippewa County - Montevideo HospitalMontevideoMinnesota56265-
Hubert H. Humphrey Cancer Center at North Memorial Medical CenterRobbinsdaleMinnesota55422-2900-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
CentraCare Clinic - River CampusSaint CloudMinnesota56303-
Coborn Cancer CenterSaint CloudMinnesota56303-
CCOP - Metro-MinnesotaSaint Louis ParkMinnesota55416-
Park Nicollet Health ServicesSaint Louis ParkMinnesota55416-
Regions Hospital Cancer Care CenterSaint PaulMinnesota55101-
St. Joseph's HospitalSaint PaulMinnesota55102-
United HospitalSaint PaulMinnesota55102-
Adult and Pediatric Urology, P.L.L.P.SartellMinnesota56377-
Saint Francis Cancer CenterShakopeeMinnesota55379-
Ridgeview Medical CenterWaconiaMinnesota55387-
Minnesota Oncology Hematology, PA - WoodburyWoodburyMinnesota55125-
Woodwinds Health CampusWoodburyMinnesota55125-
Cancer Resource Center - LincolnLincolnNebraska68510-
Alegant Health Cancer Center at Bergan Mercy Medical CenterOmahaNebraska68124-
CCOP - Missouri Valley Cancer ConsortiumOmahaNebraska68106-
Creighton University Medical CenterOmahaNebraska68131-2197-
Immanuel Medical CenterOmahaNebraska68122-
Bismarck Cancer CenterBismarckNorth Dakota58501-
Cancer Care Center at Medcenter One HospitalBismarckNorth Dakota58501-
Mid Dakota Clinic, P. C.BismarckNorth Dakota58501-
St. Alexius Medical CenterBismarckNorth Dakota58502-
CCOP - MeritCare HospitalFargoNorth Dakota58122-
MeritCare Medical GroupFargoNorth Dakota58122-
Wood County Oncology CenterBowling GreenOhio43402-
CCOP - DaytonDaytonOhio45429-
David L. Rike Cancer Center at Miami Valley HospitalDaytonOhio45409-
Good Samaritan HospitalDaytonOhio45406-
Grandview HospitalDaytonOhio45405-
Samaritan North Cancer Care CenterDaytonOhio45415-
Veterans Affairs Medical Center - DaytonDaytonOhio45428-
Blanchard Valley Medical AssociatesFindlayOhio45840-
Fremont Memorial HospitalFremontOhio43420-
Kenton Oncology, IncorporatedKentonOhio43326-
Charles F. Kettering Memorial HospitalKetteringOhio45429-
Lima Memorial HospitalLimaOhio45804-
Northwest Ohio Oncology CenterMaumeeOhio43537-
St. Luke's HospitalMaumeeOhio43537-
Middletown Regional HospitalMiddletownOhio45044-
St. Charles Mercy HospitalOregonOhio43616-
Toledo Clinic - OregonOregonOhio43616-
Firelands Regional Medical CenterSanduskyOhio44870-
North Coast Cancer Care, IncorporatedSanduskyOhio44870-
Flower Hospital Cancer CenterSylvaniaOhio43560-
Mercy Hospital of TiffinTiffinOhio44883-
CCOP - Toledo Community HospitalToledoOhio43623-
Medical University of Ohio Cancer CenterToledoOhio43614-
St. Vincent Mercy Medical CenterToledoOhio43608-
Toledo Clinic, Incorporated - Main ClinicToledoOhio43623-
Toledo HospitalToledoOhio43606-
UVMC Cancer Care Center at Upper Valley Medical CenterTroyOhio45373-1300-
Fulton County Health CenterWauseonOhio43567-
United States Air Force Medical Center - Wright-PattersonWright-Patterson AFBOhio45433-5529-
Ruth G. McMillan Cancer Center at Greene Memorial HospitalXeniaOhio45385-
Natalie Warren Bryant Cancer Center at St. Francis HospitalTulsaOklahoma74136-
Geisinger Medical CenterDanvillePennsylvania17822-0001-
Allegheny Cancer Center at Allegheny General HospitalPittsburghPennsylvania15212-
Geisinger Medical Group - Scenery ParkState CollegePennsylvania16801-
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical CenterWilkes-BarrePennsylvania18711-
Avera Cancer InstituteSioux FallsSouth Dakota57105-
Medical X-Ray Center, PCSioux FallsSouth Dakota57105-
Sioux Valley Hospital and University of South Dakota Medical CenterSioux FallsSouth Dakota57117-5039-
Central Wisconsin Cancer Program at Agnesian HealthCareFond du LacWisconsin54935-

Find similar trials in Scottsdale, AZ

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Mayo Clinic Scottsdale· Scottsdale, AZMayo Clinic - Jacksonville· Jacksonville, FLRush-Copley Cancer Care Center· Aurora, ILSt. Joseph Medical Center· Bloomington, ILGraham Hospital· Canton, ILMemorial Hospital· Carthage, IL

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