Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Non-Hodgkin's Lymphoma

Part of paid clinical trials in Little Rock, Arkansas.

Sponsor
Alliance for Clinical Trials in Oncology
Study ID
NCT00062114
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • rituximab — BIOLOGICAL
  • yttrium Y 90 ibritumomab tiuxetan — RADIATION

Study Details

RATIONALE: Monoclonal antibodies such as yttrium Y 90 ibritumomab tiuxetan and rituximab can locate cancer cells and either kill them or deliver radioactive cancer-killing substances to them without harming normal cells. PURPOSE: This phase II trial is studying how well giving yttrium Y 90 ibritumomab tiuxetan together with rituximab works in treating patients with progressive non-Hodgkin's lymphoma.

Key Dates

Start date
Apr 30, 2004
Status verified
Jul 2016
Primary completion
Apr 30, 2007
Completion
Apr 30, 2007

Study Design

Enrollment
84 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: rituximab + yttrium Y 90 ibritumomab tiuxetan
    Patients receive rituximab IV followed within 4 hours by yttrium Y 90 ibritumomab tiuxetan IV (for imaging) over 10 minutes on day 1. Patients undergo 1 (or 2 if needed) imaging scan between days 2-5. In the absence of altered biodistribution, patients receive rituximab IV followed within 4 hours by yttrium Y 90 ibritumomab tiuxetan IV over 10 minutes on day 8. Patients are followed monthly for 3 months, every 3 months for 2 years, and then every 6 months for 2 years.

Primary Outcome Measure

Overall response rate [ Time Frame: Up to 4 years ]

Locations (94)

FacilityCityStateZIPSite coordinators
Arkansas Cancer Research Center at University of Arkansas for Medical SciencesLittle RockArkansas72205-
Providence Saint Joseph Medical Center - BurbankBurbankCalifornia91505-
Moores UCSD Cancer CenterLa JollaCalifornia92093-0658-
Kaiser Permanente Medical Office -Vandever Medical OfficeSan DiegoCalifornia92120-
Beebe Medical CenterLewesDelaware19958-
CCOP - Christiana Care Health ServicesNewarkDelaware19713-
Rush-Copley Cancer Care CenterAuroraIllinois60507-
University of Chicago Cancer Research CenterChicagoIllinois60637-1470-
University of Illinois Cancer CenterChicagoIllinois60612-7243-
Joliet Oncology-Hematology Associates, Limited - WestJolietIllinois60435-
Carle Cancer Center at Carle Foundation HospitalUrbanaIllinois61801-
CCOP - Carle Cancer CenterUrbanaIllinois61801-
St. Francis Hospital and Health Centers - Beech Grove CampusBeech GroveIndiana46107-
Saint Anthony Memorial Health CentersMichigan CityIndiana46360-
Reid Hospital & Health Care Services, IncorporatedRichmondIndiana47374-
Tammy Walker Cancer Center at Salina Regional Health CenterSalinaKansas67401-
Cotton-O'Neil Cancer CenterTopekaKansas66604-
St. Francis Comprehensive Cancer CenterTopekaKansas66606-
Central Maine Comprehensive Cancer Center at Central Maine Medical CenterLewistonMaine04240-
Union Hospital Cancer Program at Union HospitalElkton MDMaryland21921-
Cancer Research Center at Boston Medical CenterBostonMassachusetts02118-
Dana-Farber/Brigham and Women's Cancer CenterBostonMassachusetts02115-
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer InstituteBostonMassachusetts02115-
Bronson Methodist HospitalKalamazooMichigan49007-
West Michigan Cancer CenterKalamazooMichigan49007-3731-
Borgess Medical CenterKalamazooaaMichigan49001-
CCOP - Cancer Research for the OzarksSpringfieldMissouri65802-
Hulston Cancer Center at Cox Medical Center SouthSpringfieldMissouri65807-
St. John's Regional Health CenterSpringfieldMissouri65804-
Billings Clinic - DowntownBillingsMontana59107-7000-
Billings Clinic Cancer CenterBillingsMontana59107-5100-
CCOP - Montana Cancer ConsortiumBillingsMontana59101-
Hematology-Oncology Centers of the Northern Rockies - BillingsBillingsMontana59101-
Northern Rockies Radiation Oncology CenterBillingsMontana59101-
St. Vincent Healthcare Cancer Care ServicesBillingsMontana59101-
Bozeman Deaconess Cancer CenterBozemanMontana59715-
St. James Healthcare Cancer CareButteMontana59701-
-Great FallsMontana59405-
Great Falls Clinic - Main FacilityGreat FallsMontana59405-
St. Peter's HospitalHelenaMontana59601-
Glacier Oncology, PLLCKalispellMontana59901-
Kalispell Medical Oncology at KRMCKalispellMontana59901-
Kalispell Regional Medical CenterKalispellMontana59901-
Community Medical CenterMissoulaMontana59801-
Guardian Oncology and Center for WellnessMissoulaMontana59804-
Montana Cancer Center at St. Patrick Hospital and Health Sciences CenterMissoulaMontana59807-
Montana Cancer Specialists at Montana Cancer CenterMissoulaMontana59807-7877-
Methodist Estabrook Cancer CenterOmahaNebraska68114-
Kingsbury Center for Cancer Care at Cheshire Medical CenterKeeneNew Hampshire03431-
Norris Cotton Cancer Center at Dartmouth - Hitchcock Medical CenterLebanonNew Hampshire03756-0002-
Frisbie Memorial HospitalRochesterNew Hampshire03867-
Cancer Institute of New Jersey at Cooper - VoorheesVoorhees TownshipNew Jersey08043-
Charles R. Wood Cancer Center at Glens Falls HospitalGlens FallsNew York12801-
New York Weill Cornell Cancer Center at Cornell UniversityNew YorkNew York10021-
Stony Brook University Cancer CenterStony BrookNew York11794-8174-
Our Lady of Mercy Medical Center Comprehensive Cancer CenterThe BronxNew York10466-
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel HillChapel HillNorth Carolina27599-7295-
Wayne Memorial Hospital, IncorporatedGoldsboroNorth Carolina27534-
Wayne Radiation OncologyGoldsboroNorth Carolina27534-
Rutherford HospitalRutherfordtonNorth Carolina28139-
Wilson Medical CenterWilsonNorth Carolina27893-3428-
Wake Forest University Comprehensive Cancer CenterWinston-SalemNorth Carolina27157-1096-
Case Comprehensive Cancer CenterClevelandOhio44106-
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State UniversityColumbusOhio43210-1240-
CCOP - DaytonDaytonOhio45429-
David L. Rike Cancer Center at Miami Valley HospitalDaytonOhio45409-
Good Samaritan HospitalDaytonOhio45406-
Grandview HospitalDaytonOhio45405-
Samaritan North Cancer Care CenterDaytonOhio45415-
Veterans Affairs Medical Center - DaytonDaytonOhio45428-
Blanchard Valley Medical AssociatesFindlayOhio45840-
Charles F. Kettering Memorial HospitalKetteringOhio45429-
Middletown Regional HospitalMiddletownOhio45044-
UVMC Cancer Care Center at Upper Valley Medical CenterTroyOhio45373-1300-
Ruth G. McMillan Cancer Center at Greene Memorial HospitalXeniaOhio45385-
St. Luke's Cancer Network at St. Luke's HospitalBethlehemPennsylvania18015-
AnMed Cancer CenterAndersonSouth Carolina29621-
CCOP - Upstate CarolinaSpartanburgSouth Carolina29303-
Gibbs Regional Cancer Center at Spartanburg Regional Medical CenterSpartanburgSouth Carolina29303-
Avera Cancer InstituteSioux FallsSouth Dakota57105-
Sioux Valley Hospital and University of South Dakota Medical CenterSioux FallsSouth Dakota57117-5039-
CCOP - Scott and White HospitalTempleTexas76508-
American Fork HospitalAmerican ForkUtah84003-
Logan Regional HospitalLoganUtah84321-
Cottonwood Hospital Medical CenterMurrayUtah84107-
McKay-Dee Hospital CenterOgdenUtah84403-
Utah Valley Regional Medical Center - ProvoProvoUtah84604-
Latter Day Saints HospitalSalt Lake CityUtah84143-
Utah Cancer Specialists at UCS Cancer CenterSalt Lake CityUtah84106-
Dixie Regional Medical Center - East CampusSt. GeorgeUtah84770-
Mountainview MedicalBerlin CornersVermont05602-
Fletcher Allen Health Care - University Health Center CampusBurlingtonVermont05401-
Virginia Commonwealth University Massey Cancer CenterRichmondVirginia23298-0037-
Welch Cancer Center at Sheridan Memorial HospitalSheridanWyoming82801-

Find similar trials in Little Rock, AR

By research site
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences· Little Rock, ARProvidence Saint Joseph Medical Center - Burbank· Burbank, CAMoores UCSD Cancer Center· La Jolla, CAKaiser Permanente Medical Office -Vandever Medical Office· San Diego, CABeebe Medical Center· Lewes, DECCOP - Christiana Care Health Services· Newark, DE

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