Combination Chemotherapy in Treating Children With Solid Tumors That Have Not Responded to Previous Therapy

Part of paid clinical trials in Duarte, California.

Sponsor
Children's Oncology Group
Study ID
NCT00006095
Phase
PHASE1
Status
Completed

Conditions

  • Unspecified Childhood Solid Tumor, Protocol Specific

Eligibility Criteria

Sex
ALL
Age
1 Year - 21 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of vincristine plus irinotecan in treating children who have solid tumors that have not responded to previous therapy.

Key Dates

Start date
Jul 31, 2000
Status verified
Feb 2014
Primary completion
Jan 31, 2005
Completion
Sep 30, 2005

Study Design

Enrollment
20 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Vincristine Sulfate 1.5 mg/m2/wk and Irinotecan
  • Experimental: Vincristine sulfate 2.0 mg/m2/wk and Irinotecan

Primary Outcome Measure

Progression Free Survival [ Time Frame: Length of study ]

Locations (21)

FacilityCityStateZIPSite coordinators
Cancer Center and Beckman Research Institute, City of HopeDuarteCalifornia91010-3000-
Children's Hospital Los AngelesLos AngelesCalifornia90027-0700-
Jonsson Comprehensive Cancer Center, UCLALos AngelesCalifornia90095-1781-
Children's Hospital of Orange CountyOrangeCalifornia92868-
UCSF Cancer Center and Cancer Research InstituteSan FranciscoCalifornia94143-0128-
Children's National Medical CenterWashington D.C.District of Columbia20010-2970-
Indiana University Cancer CenterIndianapolisIndiana46202-5289-
University of Michigan Comprehensive Cancer CenterAnn ArborMichigan48109-0752-
University of Minnesota Cancer CenterMinneapolisMinnesota55455-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
Children's Mercy HospitalKansas CityMissouri64108-
Memorial Sloan-Kettering Cancer CenterNew YorkNew York10021-
Mount Sinai School of MedicineNew YorkNew York10029-
NYU School of Medicine's Kaplan Comprehensive Cancer CenterNew YorkNew York10016-
Children's Hospital Medical Center - CincinnatiCincinnatiOhio45229-3039-
Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104-
Children's Hospital of PittsburghPittsburghPennsylvania15213-
Vanderbilt-Ingram Cancer CenterNashvilleTennessee37232-6838-
University of Texas - MD Anderson Cancer CenterHoustonTexas77030-4009-
Children's Hospital and Regional Medical Center - SeattleSeattleWashington98105-
University of Wisconsin Comprehensive Cancer CenterMadisonWisconsin53792-6164-

Find similar trials in Duarte, CA

By research site
Cancer Center and Beckman Research Institute, City of Hope· Duarte, CAChildren's Hospital Los Angeles· Los Angeles, CAJonsson Comprehensive Cancer Center, UCLA· Los Angeles, CAChildren's Hospital of Orange County· Orange, CAUCSF Cancer Center and Cancer Research Institute· San Francisco, CAChildren's National Medical Center· Washington D.C., DC

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