Paid Clinical Trials in Tennessee

Tennessee has 2,156 paid clinical trials enrolling now across cities including Nashville, Memphis and Knoxville. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Tennessee include Vanderbilt University Medical Center and St. Jude Children's Research Hospital, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,156 clinical trials

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

Apply to this trial

A Study of HLD-0117 in Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

4 locations incl. New Haven

Sponsor: Halda Therapeutics OpCo, Inc.

Sex: Female·Age: 18+

Code: NCT07524855·Phase 1·Recruiting

Apply to this trial

Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension

for Pulmonary Hypertension

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18 - 85

Code: NCT07563322·Recruiting

Apply to this trial

Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

for Atrial Fibrillation (AF)

22 locations incl. Birmingham

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT07298473·Recruiting

Apply to this trial

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

for Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)

5 locations incl. Irvine

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07403721·Phase 1·Recruiting

Apply to this trial

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

for Non-Small-Cell Lung

4 locations incl. Denver

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07519655·Phase 1·Recruiting

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

19 locations incl. Anaheim

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting

Apply to this trial

Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

for Obesity

19 locations incl. Chandler

Sponsor: Kailera

Sex: All·Age: 18 - 75

Code: NCT07497880·Phase 2·Recruiting

Apply to this trial

Extensively Hydrolyzed Formula Growth Monitioring Study (GMS)

for Growth

12 locations incl. Birmingham

Sponsor: Mead Johnson Nutrition

Sex: All·Age: 10 Days - 14 Days·Accepts healthy volunteers

Code: NCT07513506·Not Yet Recruiting

INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

for Heart Failure

7 locations incl. Tampa

Sponsor: Abiomed Inc.

Sex: All·Age: 18 - 80

Code: NCT06965504·Not Yet Recruiting

Sibwatch: Optimizing Intervention Options for Infants and Toddler Siblings of Autistic Children

for Autism Sibling

2 locations incl. Nashville

Sponsor: University of Texas at Austin

Sex: All·Age: 6 Months - 24 Months

Code: NCT07069413·Recruiting

Apply to this trial

Evaluating Health Outcomes of AI-Based Fitness Wearables & App Programs in Elderly With Cognitive Decline

for Older Adults With Cognitive Decline

1 location in Knoxville

Sponsor: The University of Tennessee, Knoxville

Sex: All·Age: 65+

Code: NCT07207993·Not Yet Recruiting

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

24 locations incl. Birmingham

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting

Apply to this trial

Evaluation of the HeartLogic Diagnostic in Optimizing Guideline-directed Medical Therapy in Patients With Congestive Heart Failure and Chronically Low Ejection Fractions (EFs)

for Congestive Heart Failure Chronic

2 locations incl. Indianapolis

Sponsor: Robert Pickett

Sex: All·Age: 18+

Code: NCT07412626·Not Yet Recruiting

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

18 locations incl. Orange

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3·Recruiting

Apply to this trial

APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)

for Acute Uncomplicated Diverticulitis

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18 - 90

Code: NCT07492134·Phase 2·Not Yet Recruiting

NPX372, a B7-H7:CD3 Bispecific Antibody, in Selected Solid Tumor Malignancies

for Metastatic Malignant Neoplasm

6 locations incl. La Jolla

Sponsor: NextPoint Therapeutics, Inc.

Sex: All·Age: 19+

Code: NCT07563829·Phase 1·Not Yet Recruiting

Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest

for Post-Cardiac Arrest Syndrome

8 locations incl. Hartford

Sponsor: Invero Pharma, Inc.

Sex: All·Age: 18 - 80

Code: NCT03176186·Phase 3·Not Yet Recruiting

Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia

for Survivor of Childhood Cancer

1 location in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 20 - 50

Code: NCT07191119·Recruiting

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A Study of TORL-5-700 in Relapsed/Refractory Non Hodgkin's Lymphoma

for Histologically Confirmed Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

3 locations incl. Santa Monica

Sponsor: TORL Biotherapeutics, LLC

Sex: All·Age: 18+

Code: NCT07439653·Phase 1, Phase 2·Recruiting

Apply to this trial

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

for Epidermal Growth Factor

6 locations incl. Los Angeles

Sponsor: EpiBiologics

Sex: All·Age: 18+

Code: NCT07462377·Phase 1·Recruiting

Apply to this trial

MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

for Pharmacokinetics

1 location in Knoxville

Sponsor: Resilient Pharmaceuticals

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT03606538·Phase 1·Not Yet Recruiting

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

for Brain Cancer

Drug: Nivolumab

1 location in Nashville

Sponsor: Eben Rosenthal

Sex: All·Age: 18+

Code: NCT07210632·EARLY_Phase 1·Recruiting

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Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

for Breast Neoplasms

39 locations incl. Birmingham

Sponsor: Natera, Inc.

Sex: All·Age: 18+

Code: NCT07214532·Recruiting

Apply to this trial

Continuous Dual Aspiration Technique With Zoom System for Stroke

for Ischemic Stroke

13 locations incl. Huntsville

Sponsor: Imperative Care, Inc.

Sex: All·Age: 18+

Code: NCT07491952·Recruiting

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A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

for Multiple Sclerosis (MS) Primary Progressive

11 locations incl. Pheonix

Sponsor: Zenas BioPharma (USA), LLC

Sex: All·Age: 18 - 60

Code: NCT07067463·Phase 3·Recruiting

Apply to this trial

PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease

for Proteinuric Kidney Diseases

25 locations incl. Huntsville

Sponsor: Boehringer Ingelheim

Sex: All·Age: 12+

Code: NCT07355296·Phase 2·Recruiting

Apply to this trial

Study in Advanced Solid Tumor Patients

for Advanced Solid Tumor

5 locations incl. Boston

Sponsor: Callio Therapeutics

Sex: All·Age: 18+

Code: NCT07300943·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1

for HIV

8 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07390955·Phase 1·Recruiting

Apply to this trial

A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris

for Lichen Planopilaris

5 locations incl. Phoenix

Sponsor: Priovant Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07532603·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Investigate Ubamatamab With and Without REGN7075 in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Advanced/Metastatic Non-Small Cell Lung Cancer

5 locations incl. Goodyear

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07154290·Phase 2·Recruiting

Apply to this trial

A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

for Adenovirus Infections

26 locations incl. Phoenix

Sponsor: SymBio Pharmaceuticals

Sex: All·Age: 2 Months+

Code: NCT07387367·Phase 3·Recruiting

Apply to this trial

The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms

for Hemorrhagic Stroke

17 locations incl. Phoenix

Sponsor: phenox Inc.

Sex: All·Age: 18+

Code: NCT07143019·Recruiting

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A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

for Hepatocellular Carcinoma (HCC)

Drug: Ipilimumab

9 locations incl. Los Angeles

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07291076·Phase 1, Phase 2·Recruiting

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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

for Obesity or Overweight

Drug: Enicepatide

25 locations incl. Anniston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07351045·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

for Non-small Cell Lung Cancer (NSCLC)

Drug: Durvalumab

38 locations incl. Daphne

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07361497·Phase 3·Recruiting

Apply to this trial

Endoscopic COlorectal Mucosal Evaluation of Oxygen Tension

for Anastomotic Leak Rectum

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07467980·Recruiting

Apply to this trial

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH)

for Idiopathic Hypersomnia

12 locations incl. Santa Monica

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 18+

Code: NCT07500090·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

Drug: Nivolumab

34 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221149·Phase 2, Phase 3·Recruiting

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Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

for Urothelial Cancer

Drug: PF-08634404

39 locations incl. Fayetteville

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07421700·Phase 1, Phase 2·Recruiting

Apply to this trial