Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcomafor Endometrial Carcinoma403 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05256225·Phase 3·RecruitingApply to this trial
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detectionfor Acute Lymphoblastic Leukemia746 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 40 - 75·Accepts healthy volunteersCode: NCT05334069·RecruitingApply to this trial
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Diseasefor Stage III Colon Cancer1021 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05174169·Phase 2, Phase 3·RecruitingApply to this trial
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinomafor Endometrial AdenocarcinomaDrug: Ipilimumab137 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05112601·Phase 2·RecruitingApply to this trial
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumorsfor Metastatic Malignant Neoplasm in the Liver446 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05040360·Phase 2·RecruitingApply to this trial
Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphomafor Lymphoplasmacytic LymphomaDrug: Venetoclax131 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04840602·Phase 2·RecruitingApply to this trial
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumorsfor Malignant Solid Neoplasm843 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT04871542·RecruitingApply to this trial
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)for Stage I Breast Cancer812 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 50 - 70Code: NCT04852887·Phase 3·RecruitingApply to this trial
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutationfor Pancreatic Acinar Cell CarcinomaDrug: Olaparib452 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04858334·Phase 2·RecruitingApply to this trial
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Studyfor Chronic Lymphocytic Leukemia621 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04269902·Phase 3·RecruitingApply to this trial
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trialfor Plasma Cell Myeloma642 locations incl. AnchorageSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT04566328·Phase 3·RecruitingApply to this trial
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastasesfor Acral Lentiginous MelanomaDrug: Ipilimumab331 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT04511013·Phase 2·RecruitingApply to this trial
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancerfor Advanced Lung Non-Squamous Non-Small Cell CarcinomaDrug: Bevacizumab604 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04181060·Phase 3·RecruitingApply to this trial
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imagingfor Biochemically Recurrent Prostate CarcinomaDrug: Apalutamide342 locations incl. AnchorageSponsor: ECOG-ACRIN Cancer Research GroupSex: Male·Age: 18+Code: NCT04423211·Phase 3·RecruitingApply to this trial
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancerfor Ovarian Carcinoma539 locations incl. BirminghamSponsor: NRG OncologySex: Female·Age: 35 - 50Code: NCT04251052·RecruitingApply to this trial
Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkersfor Pancreatic Neoplasm408 locations incl. BirminghamSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 50 - 75Code: NCT04239573·RecruitingApply to this trial
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])for Lung Non-Small Cell Carcinoma1150 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04267848·Phase 3·RecruitingApply to this trial
Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancersfor Metastatic Small Intestinal Adenocarcinoma536 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT04205968·Phase 2·RecruitingApply to this trial
Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effectsfor Malignancy626 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: All·Age: All agesCode: NCT04242095·RecruitingApply to this trial
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myelomafor Smoldering Plasma Cell MyelomaDrug: Daratumumab741 locations incl. BirminghamSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT03937635·Phase 3·RecruitingApply to this trial
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumorsfor Bladder AdenocarcinomaDrug: Cabozantinib578 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT03866382·Phase 2·RecruitingApply to this trial
Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemiafor B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative275 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT03739814·Phase 2·RecruitingApply to this trial
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancerfor Previously Treated Non-Small Cell Lung Cancer1229 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT03851445·Phase 2, Phase 3·RecruitingApply to this trial
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancerfor Breast Cancer451 locations incl. FairbanksSponsor: Canadian Cancer Trials GroupSex: Female·Age: 35+Code: NCT03488693·Phase 3·RecruitingApply to this trial
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancerfor Anatomic Stage IV Breast Cancer AJCC v8709 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT03723928·RecruitingApply to this trial
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Changefor Advanced Lung Non-Small Cell CarcinomaDrug: Osimertinib345 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT03191149·Phase 2·RecruitingApply to this trial
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicityfor Cardiotoxicity577 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT03418961·Phase 3·RecruitingApply to this trial
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemiafor B Acute Lymphoblastic Leukemia455 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18 - 39Code: NCT03150693·Phase 3·RecruitingApply to this trial
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumorsfor Childhood Extracranial Germ Cell Tumor566 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: All agesCode: NCT03067181·Phase 3·RecruitingApply to this trial
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgeryfor Head and Neck Squamous Cell Carcinoma676 locations incl. BirminghamSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT02734537·Phase 2·RecruitingApply to this trial
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomasfor Intracranial Meningioma780 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT02523014·Phase 2·RecruitingApply to this trial