Paid Clinical Trials in Orlando, FL

As of June 2026, 757 paid clinical trials are recruiting in Orlando, Florida. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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757 clinical trials

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Serious Gaming for Chemotherapy-induced Nausea and Vomiting

for Neoplasms

2 locations incl. Miami

Sponsor: University of Central Florida

Sex: All·Age: 60+

Code: NCT05838638·Recruiting

Apply to this trial

Tumor-Derived FGF19

for Colorectal Cancer

1 location in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06068257·Recruiting

Apply to this trial

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for Glioma

40 locations incl. Birmingham

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT05303519·Phase 3·Recruiting

Apply to this trial

Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

for Colonic Neoplasms

3 locations incl. Oakland

Sponsor: AdventHealth Translational Research Institute

Sex: All·Age: 18+

Code: NCT05773144·Recruiting

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ML-004 Open-Label Extension Study in Adults and Adolescents With Autism Spectrum Disorders (ASD)

for Autism Spectrum Disorder

18 locations incl. Dothan

Sponsor: MapLight Therapeutics

Sex: All·Age: 12 - 46

Code: NCT05889273·Phase 2·Enrolling By Invitation

Cell-Free DNA Chromatin Immunoprecipitation (ChIP) for Diagnosing Cancer

for Cancer of Pancreas

1 location in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 18+

Code: NCT06148298·Recruiting

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A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

for Myositis

47 locations incl. Glendale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05895786·Phase 3·Recruiting

Apply to this trial

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

390 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting

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A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

for Advanced Prostate Cancer

5 locations incl. Scottsdale

Sponsor: Genentech, Inc.

Sex: Male·Age: 18+

Code: NCT05800665·Phase 1·Recruiting

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Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

for Colonic Neoplasms

1 location in Orlando

Sponsor: AdventHealth Translational Research Institute

Sex: All·Age: 18+

Code: NCT05789433·Recruiting

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An Open-label Study of XEN1101 in Epilepsy

for Focal Epilepsy

53 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05718817·Phase 3·Enrolling By Invitation

Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury

for Acute Kidney Injury

38 locations incl. Birmingham

Sponsor: SeaStar Medical

Sex: All·Age: 18+

Code: NCT05758077·Recruiting

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Optimizing a Technology-based Body and Mind Intervention

for Fall

1 location in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT05778604·Recruiting

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

20 locations incl. Phoenix

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting

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A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions

for Narcolepsy Type 1

19 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 16 - 70

Code: NCT05816382·Phase 2, Phase 3·Recruiting

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A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

for Breast Cancer, Early Breast Cancer

Drug: Camizestrant

129 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT05774951·Phase 3·Recruiting

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Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

for Metastatic Melanoma

Drug: Lifileucel

22 locations incl. Birmingham

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT05727904·Phase 3·Recruiting

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Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

for Breast Cancer

15 locations incl. Orlando

Sponsor: Incyclix Bio

Sex: All·Age: 18+

Code: NCT05735080·Phase 1, Phase 2·Recruiting

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A Post-Authorisation Safety Study (PASS) of Patients Treated With Lonapegsomatropin

for Growth Hormone Deficiency

27 locations incl. Phoenix

Sponsor: Ascendis Pharma Endocrinology Division A/S

Sex: All·Age: 1 - 18

Code: NCT05775523·Recruiting

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A US Non-interventional, Effectiveness and Safety Study of Patients Treated With SKYTROFA

for Growth Hormone Deficiency

27 locations incl. Phoenix

Sponsor: Ascendis Pharma Endocrinology Division A/S

Sex: All·Age: All ages

Code: NCT05820672·Recruiting

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Vivistim Registry for Paired VNS Therapy (GRASP)

for Upper Extremity Problem

15 locations incl. Orlando

Sponsor: MicroTransponder Inc.

Sex: All·Age: 22+

Code: NCT05301140·Recruiting

Apply to this trial

A Safety and Effectiveness Prospective Blinded Clinical Study to Validate xBar System as Monitoring Tool for Anastomotic Leaks Detection

for Colorectal Surgery

10 locations incl. Orlando

Sponsor: Exero Medical Ltd.

Sex: All·Age: 22+

Code: NCT06168669·Recruiting

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A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

for High Grade Osteosarcoma

Drug: Cabozantinib

175 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 40

Code: NCT05691478·Phase 2, Phase 3·Recruiting

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Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

for Ductus Arteriosus, Patent

24 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 7 Days - 32 Days

Code: NCT05547165·Recruiting

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

101 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting

Apply to this trial

Using a mHealth Intervention to Promote Physical Activity in Phase III Cardiac Rehabilitation Clients

for Cardiac Rehabilitation

1 location in Orlando

Sponsor: AdventHealth University

Sex: All·Age: 18 - 99

Code: NCT05795036·Recruiting

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Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C

for Irritable Bowel Syndrome With Constipation (IBS-C)

Drug: Tenapanor

27 locations incl. Foley

Sponsor: Ardelyx

Sex: All·Age: 6 - 18

Code: NCT05905926·Phase 3·Enrolling By Invitation

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

for Primary Generalized Tonic-Clonic Seizures

59 locations incl. Mobile

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05667142·Phase 3·Recruiting

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A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition

for Metabolic Dysfunction-Associated SteatoHepatitis (MASH)

61 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT05519475·Phase 2·Recruiting

Apply to this trial

A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib

for Endometrioid Cancer

Drug: Avutometinib

4 locations incl. Orlando

Sponsor: University of Oklahoma

Sex: Female·Age: 18 - 99

Code: NCT05512208·Phase 2·Recruiting

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ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

for B-cell Lymphoma

5 locations incl. Orlando

Sponsor: Acepodia Biotech, Inc.

Sex: All·Age: 18+

Code: NCT05653271·Phase 1·Recruiting

Apply to this trial

FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

for Urinary Bladder Neoplasms

41 locations incl. Tucson

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05614739·Phase 1·Recruiting

Apply to this trial

Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

for Medulloblastoma

10 locations incl. Palo Alto

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 59 Months

Code: NCT05535166·Phase 2·Recruiting

Apply to this trial

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

for Advanced Melanoma

Drug: Tebentafusp

25 locations incl. Phoenix

Sponsor: Immunocore Ltd

Sex: All·Age: 18+

Code: NCT05549297·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

for Ulcerative Colitis

20 locations incl. Little Rock

Sponsor: Pfizer

Sex: All·Age: 12 - 17

Code: NCT05287126·Phase 2·Recruiting

Apply to this trial

Study of CHS-114 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

16 locations incl. Newport Beach

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05635643·Phase 1·Recruiting

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Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

for Triple Negative Breast Cancer

184 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05633654·Phase 3·Recruiting

Apply to this trial

Evaluation of 3D Printed Myoelectric Prosthetic Devices in Children With Upper Congenital Limb Deficiency

for Limb Deformities, Congenital

1 location in Orlando

Sponsor: Orlando Health, Inc.

Sex: All·Age: 7 - 17

Code: NCT05547308·Not Yet Recruiting

Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation

for Advanced NSCLC

Drug: Adagrasib

84 locations incl. Anchorage

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05609578·Phase 2·Recruiting

Apply to this trial