Oncology Clinical Trials in Orlando, FL

As of June 2026, 164 paid clinical trials are recruiting for Oncology in Orlando, Florida. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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164 clinical trials for Oncology

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A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

16 locations incl. Fountain Valley

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05932862·Phase 1·Recruiting

Apply to this trial

A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors

for Solid Tumor, Adult

15 locations incl. Birmingham

Sponsor: Corbus Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06265727·Phase 1, Phase 2·Recruiting

Apply to this trial

EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope

for Pancreatic Disease

1 location in Orlando

Sponsor: Orlando Health, Inc.

Sex: All·Age: 18 - 100

Code: NCT06340620·Recruiting

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A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

for Non Small Cell Lung Cancer

9 locations incl. Margate

Sponsor: Compass Therapeutics

Sex: All·Age: 18+

Code: NCT06150664·Phase 1·Recruiting

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A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration-Resistant Prostate Cancer

9 locations incl. Duarte

Sponsor: AbbVie

Sex: Male·Age: 18+

Code: NCT06318273·Phase 1·Recruiting

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Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

17 locations incl. Birmingham

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting

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Artificial Intelligence in Endoscopic Ultrasound

for Pancreatic Cancer

1 location in Orlando

Sponsor: Orlando Health, Inc.

Sex: All·Age: 18 - 100

Code: NCT06564571·Recruiting

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

91 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

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CLN-617 Alone and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

5 locations incl. Los Angeles

Sponsor: Cullinan Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06035744·Phase 1·Recruiting

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A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

for Non-small Cell Lung Cancer

Drug: Intismeran autogene

68 locations incl. Anchorage

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06077760·Phase 3·Recruiting

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Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

for Breast Cancer

79 locations incl. Phoenix

Sponsor: BriaCell Therapeutics Corporation

Sex: All·Age: 18+

Code: NCT06072612·Phase 3·Recruiting

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A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer

for Advanced Solid Tumor

8 locations incl. Phoenix

Sponsor: TORL Biotherapeutics, LLC

Sex: All·Age: 18+

Code: NCT06005740·Phase 1·Recruiting

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A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

for Colorectal Neoplasms

21 locations incl. Phoenix

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT06131840·Phase 1·Recruiting

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OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

for Breast Cancer

Drug: Palazestrant

47 locations incl. Tucson

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06016738·Phase 3·Recruiting

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JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

for Advanced Solid Tumor

10 locations incl. Encinitas

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06108050·Phase 1·Recruiting

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Safety and Efficacy of OBX-115 in Advanced Solid Tumors

for Tumor Skin

9 locations incl. Los Angeles

Sponsor: Obsidian Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06060613·Phase 1, Phase 2·Recruiting

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

1208 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting

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Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

for Cholangiocarcinoma

Drug: Trametinib

10 locations incl. Los Angeles

Sponsor: Genfit

Sex: All·Age: 18+

Code: NCT05874414·Phase 1, Phase 2·Recruiting

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A Study of DB-1310 in Advanced/Metastatic Solid Tumors

for Advanced Solid Tumor

15 locations incl. Sacramento

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05785741·Phase 1, Phase 2·Recruiting

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A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

for Advanced Solid Tumors

28 locations incl. Tucson

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05914116·Phase 1, Phase 2·Recruiting

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Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

24 locations incl. Beverly Hills

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting

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ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

for Non Small Cell Lung Cancer

46 locations incl. Dothan

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT05671510·Phase 3·Recruiting

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Serious Gaming for Chemotherapy-induced Nausea and Vomiting

for Neoplasms

2 locations incl. Miami

Sponsor: University of Central Florida

Sex: All·Age: 60+

Code: NCT05838638·Recruiting

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Tumor-Derived FGF19

for Colorectal Cancer

1 location in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06068257·Recruiting

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SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for Glioma

40 locations incl. Birmingham

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT05303519·Phase 3·Recruiting

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A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

for Advanced Prostate Cancer

5 locations incl. Scottsdale

Sponsor: Genentech, Inc.

Sex: Male·Age: 18+

Code: NCT05800665·Phase 1·Recruiting

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Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

for Metastatic Melanoma

Drug: Lifileucel

22 locations incl. Birmingham

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT05727904·Phase 3·Recruiting

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Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

for Breast Cancer

15 locations incl. Orlando

Sponsor: Incyclix Bio

Sex: All·Age: 18+

Code: NCT05735080·Phase 1, Phase 2·Recruiting

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A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib

for Endometrioid Cancer

Drug: Avutometinib

4 locations incl. Orlando

Sponsor: University of Oklahoma

Sex: Female·Age: 18 - 99

Code: NCT05512208·Phase 2·Recruiting

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ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

for B-cell Lymphoma

5 locations incl. Orlando

Sponsor: Acepodia Biotech, Inc.

Sex: All·Age: 18+

Code: NCT05653271·Phase 1·Recruiting

Apply to this trial

Study of CHS-114 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

16 locations incl. Newport Beach

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05635643·Phase 1·Recruiting

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Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

for Triple Negative Breast Cancer

184 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05633654·Phase 3·Recruiting

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A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

for Carcinoma, Non-small-Cell Lung

Drug: Amivantamab

26 locations incl. La Jolla

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05498428·Phase 2·Recruiting

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A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

67 locations incl. Gilbert

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05552222·Phase 3·Recruiting

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A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

for Advanced Cancer

15 locations incl. Los Angeles

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05557045·Phase 1·Recruiting

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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

45 locations incl. Phoenix

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting

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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

for Neuroblastoma

20 locations incl. Birmingham

Sponsor: Giselle Sholler

Sex: All·Age: 12 Months - 21

Code: NCT05489887·Phase 2·Recruiting

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Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

for Locoregional Recurrence

Drug: Ribociclib

20 locations incl. Birmingham

Sponsor: Oana Danciu

Sex: All·Age: 18+

Code: NCT05467891·Phase 2·Recruiting

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

42 locations incl. Phoenix

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting

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Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

16 locations incl. Los Angeles

Sponsor: ModernaTX, Inc.

Sex: All·Age: 12+

Code: NCT05533697·Phase 1, Phase 2·Recruiting

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Conditions in Oncology (Orlando, FL)

Solid tumor· 34 Non-small cell lung cancer (NSCLC)· 26 Breast cancer· 18 Ovarian cancer· 15 Cancer (any)· 14 Endometrial cancer· 13 Colorectal cancer· 12 Pancreatic cancer· 10 Neuroblastoma· 9 Esophageal cancer· 8 Cervical cancer· 8 Head and neck cancer· 8 Triple-negative breast cancer· 7 Lung cancer· 7 Gastric cancer· 7 Prostate cancer· 7 Non-Hodgkin lymphoma· 7 Metastatic breast cancer· 6 Gastroesophageal junction cancer· 6 Acute myeloid leukemia (AML)· 6 HER2-negative breast cancer· 5 Bladder cancer· 5 Small cell lung cancer· 4 Metastatic prostate cancer· 4 Fallopian tube cancer· 4 Hematologic malignancy· 4 Melanoma· 4 Osteosarcoma· 4 Biliary tract cancer· 3 Multiple myeloma· 3 Liver cancer· 2 Leukemia (other)· 2 Myelodysplastic syndromes (MDS)· 2 Hodgkin lymphoma· 2 Diffuse large B-cell lymphoma (DLBCL)· 2 Ewing sarcoma· 2 Mesothelioma· 2 HER2-positive breast cancer· 1 Metastatic colorectal cancer· 1 Rectal cancer· 1 Gastrointestinal cancer· 1 Kidney cancer· 1 Uterine cancer· 1 Gynecologic cancer· 1 Glioma· 1 Brain cancer· 1 Acute lymphoblastic leukemia· 1 Myelofibrosis· 1 Myeloproliferative neoplasm· 1 Follicular lymphoma· 1 Marginal zone lymphoma· 1 Burkitt lymphoma· 1 Rhabdomyosarcoma· 1 Pediatric cancer· 1