Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,944 clinical trials

↓ Download CSV

A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment

for Homocystinuria

13 locations incl. Phoenix

Sponsor: Travere Therapeutics, Inc.

Sex: All·Age: 12 - 65

Code: NCT06247085·Phase 3·Recruiting

Apply to this trial

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

for Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation

13 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT05691465·Phase 2·Recruiting

Apply to this trial

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

for Hypertension

70 locations incl. Scottsdale

Sponsor: Orchestra BioMed, Inc

Sex: All·Age: 18+

Code: NCT06059638·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

for Major Depressive Disorder

40 locations incl. Bellflower

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06223880·Phase 4·Recruiting

Apply to this trial

National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

18 locations incl. Los Angeles

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting

Apply to this trial

Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

for Prostate Cancer

27 locations incl. Grand Rapids

Sponsor: Clarity Pharmaceuticals Ltd

Sex: Male·Age: 18+

Code: NCT06056830·Phase 3·Recruiting

Apply to this trial

Immersive Healing: The Therapeutic Potential of Virtual Reality

for Phantom Limb Pain (PLP)

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06077227·Recruiting

Apply to this trial

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

90 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

Apply to this trial

A Multicenter Study in Bronchoscopy Combining Stimulated Raman Histology With Artificial Intelligence for Rapid Lung Cancer Detection - The ON-SITE Study

for Lung Biopsy

7 locations incl. San Diego

Sponsor: Invenio Imaging Inc.

Sex: All·Age: 22+

Code: NCT07045103·Recruiting

Apply to this trial

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)

for Hemolytic Disease of the Fetus and Newborn

Drug: Nipocalimab

18 locations incl. La Jolla

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18 - 45

Code: NCT05912517·Phase 3·Recruiting

Apply to this trial

Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma

for Cholangiocarcinoma

19 locations incl. Santa Monica

Sponsor: TransThera Sciences (Nanjing), Inc.

Sex: All·Age: 18+

Code: NCT05948475·Phase 3·Recruiting

Apply to this trial

Global Trial in APG2575 for Patients With CLL/SLL

for CLL/SLL

11 locations incl. Tuscon

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 99

Code: NCT06104566·Phase 3·Recruiting

Apply to this trial

Regulating Together in Tuberous Sclerosis Complex

for TSC

2 locations incl. Carrboro

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 8 - 17

Code: NCT06105736·Recruiting

Apply to this trial

A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

for Neoplasms

11 locations incl. Duarte

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06150157·Phase 1·Recruiting

Apply to this trial

RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy

for Idiopathic Inflammatory Myopathy

31 locations incl. Orange

Sponsor: Cabaletta Bio

Sex: All·Age: 6 - 75

Code: NCT06154252·Phase 2, Phase 3·Recruiting

Apply to this trial

A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment

for Multiple Myeloma

Drug: Linvoseltamab

13 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05828511·Phase 1, Phase 2·Recruiting

Apply to this trial

Contraceptive Efficacy Study of Ovaprene

for Contraception

27 locations incl. Phoenix

Sponsor: Daré Bioscience, Inc.

Sex: Female·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06127199·Recruiting

Apply to this trial

Cord Clamping Among Neonates With Congenital Heart Disease

for Congenital Heart Disease (CHD)

18 locations incl. Birmingham

Sponsor: Carl Backes, MD

Sex: All·Age: 37 Weeks - 42 Weeks

Code: NCT06153459·Recruiting

Apply to this trial

The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

for Toxicity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04700527·Phase 1, Phase 2·Recruiting

Apply to this trial

Vitamin D for Prostate Endocrine Therapy

for Stage I Prostate Cancer AJCC v8

51 locations incl. Newark

Sponsor: University of Rochester

Sex: Male·Age: 50+

Code: NCT05838716·Phase 3·Recruiting

Apply to this trial

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for Prostate Adenocarcinoma

388 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT05946213·Phase 3·Recruiting

Apply to this trial

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

for Locally Advanced Head and Neck Squamous Cell Carcinoma

70 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06129864·Phase 3·Recruiting

Apply to this trial

A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

for Diffuse Large B-cell Lymphoma (DLBCL)

Drug: Odronextamab

20 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06091865·Phase 3·Recruiting

Apply to this trial

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

for Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

38 locations incl. Tucson

Sponsor: Intellia Therapeutics

Sex: All·Age: 18 - 90

Code: NCT06128629·Phase 3·Recruiting

Apply to this trial

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

for Chronic Lymphocytic Leukemia

Drug: Nemtabrutinib

43 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06136559·Phase 3·Recruiting

Apply to this trial

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

for Follicular Lymphoma (FL)

Drug: Odronextamab

20 locations incl. Tucson

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06091254·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

for Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

Drug: Giredestrant

61 locations incl. Daphne

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06065748·Phase 3·Recruiting

Apply to this trial

FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)

for Type 1 Diabetes Mellitus

Drug: Frexalimab

14 locations incl. San Francisco

Sponsor: Sanofi

Sex: All·Age: 12 - 35

Code: NCT06111586·Phase 2·Recruiting

Apply to this trial

Phase II Study of Ovulation in Obese Women

for Pregnancy Prevention

1 location in Raleigh

Sponsor: InnovaGyn, Inc.

Sex: Female·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06306131·Phase 2·Recruiting

Apply to this trial

Zenith® Fenestrated+ Clinical Study

for Aortic Aneurysm, Abdominal

32 locations incl. Birmingham

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT04875429·Recruiting

Apply to this trial

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

for Cirrhosis

13 locations incl. La Jolla

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 75

Code: NCT05832229·Phase 2·Recruiting

Apply to this trial

Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation

for Kidney Transplant

15 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05917522·Phase 2·Recruiting

Apply to this trial

A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

for Choroidal Melanoma

36 locations incl. Birmingham

Sponsor: Aura Biosciences

Sex: All·Age: 18+

Code: NCT06007690·Phase 3·Recruiting

Apply to this trial

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

for Non-small Cell Lung Cancer

Drug: Intismeran autogene

68 locations incl. Anchorage

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06077760·Phase 3·Recruiting

Apply to this trial

Transforming Hemodialysis-Related Vascular Access Education

for Chronic Kidney Disease

3 locations incl. Baltimore

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05997875·Recruiting

Apply to this trial

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

for Breast Cancer

79 locations incl. Phoenix

Sponsor: BriaCell Therapeutics Corporation

Sex: All·Age: 18+

Code: NCT06072612·Phase 3·Recruiting

Apply to this trial

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

16 locations incl. Davis

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting

Apply to this trial

A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

Drug: Ruxolitinib

13 locations incl. Duarte

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06034002·Phase 1·Recruiting

Apply to this trial

Human Immunodeficiency Virus (HIV) Food Insecurities

for Food Insecurities

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT04943861·Recruiting

Apply to this trial

Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

for Esophageal Stricture

34 locations incl. Birmingham

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561114·Phase 3·Recruiting

Apply to this trial