Lung oncology Clinical Trials in Los Angeles, CA

As of June 2026, 71 paid clinical trials are recruiting for Lung oncology in Los Angeles, California. Lung oncology trials investigate EGFR, ALK, KRAS, and other driver-mutation targeted therapies alongside immunotherapy combinations for non-small cell, small cell, and mesothelioma studies. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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71 clinical trials for Lung oncology

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A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

for Solid Tumor, Adult

12 locations incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT06051695·Phase 1, Phase 2·Recruiting

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A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

for Non Small Cell Lung Cancer

49 locations incl. Little Rock

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06312137·Phase 3·Recruiting

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

18 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting

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A Study of MGC026 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

7 locations incl. Los Angeles

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT06242470·Phase 1·Recruiting

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Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

17 locations incl. Birmingham

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

91 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

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A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

for Non-small Cell Lung Cancer

Drug: Intismeran autogene

68 locations incl. Anchorage

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06077760·Phase 3·Recruiting

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Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

for Diffuse Astrocytoma, IDH-Mutant

6 locations incl. Beverly Hills

Sponsor: Neonc Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06047379·Phase 1, Phase 2·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

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Safety and Efficacy of OBX-115 in Advanced Solid Tumors

for Tumor Skin

9 locations incl. Los Angeles

Sponsor: Obsidian Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06060613·Phase 1, Phase 2·Recruiting

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Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer

for Non Small Cell Lung Cancer

Drug: Osimertinib

5 locations incl. Beverly Hills

Sponsor: Karen Reckamp, MD, MS

Sex: All·Age: 18+

Code: NCT05401110·Phase 1·Recruiting

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Utilizing Advocates and Supporters to Increase Lung Cancer Screening Rates in Eligible Participants

for Breast Carcinoma

1 location in Los Angeles

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT05978128·Recruiting

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Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

for Head and Neck Squamous Cell Carcinoma (HNSCC)

4 locations incl. Los Angeles

Sponsor: Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05985655·Phase 1, Phase 2·Recruiting

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MRI and Biomarkers for Lung Nodules Detected During Lung Cancer Screening

for Lung Cancer

1 location in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT05699213·Recruiting

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TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

for Renal Cell Cancer

3 locations incl. Los Angeles

Sponsor: Portage Biotech

Sex: All·Age: 18+

Code: NCT04969315·Phase 1, Phase 2·Recruiting

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A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

for Solid Tumor, Adult

13 locations incl. Los Angeles

Sponsor: GV20 Therapeutics

Sex: All·Age: 18+

Code: NCT05669430·Phase 1, Phase 2·Recruiting

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Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

for High Grade Epithelial Ovarian Cancer

37 locations incl. Phoenix

Sponsor: Genmab

Sex: All·Age: 18+

Code: NCT05579366·Phase 1, Phase 2·Recruiting

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A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

for Melanoma

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 16+

Code: NCT05538130·Phase 1·Recruiting

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A Study of EP0031 in Patients With Advanced RET-altered Malignancies

for Advanced Solid Tumor

Drug: EP0031

18 locations incl. Los Angeles

Sponsor: Ellipses Pharma

Sex: All·Age: 18+

Code: NCT05443126·Phase 1, Phase 2·Recruiting

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GEMINI-NSCLC: NSCLC Biomarker Study

for Non-Small Cell Lung Cancer

58 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT05236114·Recruiting

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Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

for NSCLC

21 locations incl. Davis

Sponsor: Lung Cancer Mutation Consortium

Sex: All·Age: All ages

Code: NCT04712877·Recruiting

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Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

25 locations incl. Little Rock

Sponsor: AstraZeneca

Sex: All·Age: 18 - 95

Code: NCT05061550·Phase 2·Recruiting

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A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for Non Small Cell Lung Cancer

Drug: Telisotuzumab Vedotin

50 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT04928846·Phase 3·Recruiting

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First in Human Study of TORL-1-23 in Participants With Advanced Cancer

for Advanced Solid Tumor

9 locations incl. Fullerton

Sponsor: TORL Biotherapeutics, LLC

Sex: All·Age: 18+

Code: NCT05103683·Phase 1·Recruiting

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A Study of NX-1607 in Adults With Advanced Malignancies

for Ovarian Cancer, Epithelial

10 locations incl. Duarte

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05107674·Phase 1·Recruiting

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A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

for Advanced Malignant Solid Neoplasm

3 locations incl. Los Angeles

Sponsor: RasCal Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT04678648·Phase 1·Recruiting

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A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

38 locations incl. Duarte

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT04302025·Phase 2·Recruiting

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for Advanced Solid Tumor

32 locations incl. Irvine

Sponsor: PMV Pharmaceuticals, Inc

Sex: All·Age: 12+

Code: NCT04585750·Phase 1, Phase 2·Recruiting

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

1150 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting

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A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

23 locations incl. La Jolla

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT03526835·Phase 1, Phase 2·Recruiting

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APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

for Solid Tumors

6 locations incl. Los Angeles

Sponsor: Apollomics Inc.

Sex: All·Age: 18+

Code: NCT03175224·Phase 2·Recruiting

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Conditions in Lung oncology (Los Angeles, CA)

Non-small cell lung cancer (NSCLC)· 58 Lung cancer· 19 Small cell lung cancer· 4 Mesothelioma· 3