Clinical Trials at Mayo Clinic in Florida

As of June 2026, 187 paid clinical trials are recruiting at Mayo Clinic in Florida, located at 4500 SAN PABLO RD S, JACKSONVILLE, FL 32224-1865, phone (904) 953-2000 in Jacksonville, Florida. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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187 clinical trials at Mayo Clinic in Florida

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Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

for Anatomic Stage 0 Breast Cancer AJCC v8

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT06401889·Recruiting

Apply to this trial

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

335 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting

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Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

for Localized Prostate Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Male·Age: 30 - 85

Code: NCT06389786·Recruiting

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Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma

for Locally Advanced Intrahepatic Cholangiocarcinoma

Drug: Tremelimumab

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06058663·Phase 1·Recruiting

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Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

for Recurrent Castration-Sensitive Prostate Carcinoma

3 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT06378866·Phase 2·Recruiting

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Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma

for Indolent B-Cell Non-Hodgkin Lymphoma

7 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06386315·Phase 2·Recruiting

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Building Community Living Labs in Black Communities to Advance Prostate Health Equity and Reduce Prostate Cancer Disparities in Black Men

for Prostate Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 21 - 80·Accepts healthy volunteers

Code: NCT06541210·Recruiting

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Continuous Glucose Monitor for Mayo Clinic Advanced Care at Home Patients

for Diabetes Mellitus

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05880810·Recruiting

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Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for Advanced Esophageal Squamous Cell Carcinoma

Drug: Nivolumab

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06265285·Phase 2·Recruiting

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DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Breast Cancer Patients

for HER2-negative Breast Cancer

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT06388122·Recruiting

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Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

for Early Stage Triple-Negative Breast Carcinoma

3 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06349642·Recruiting

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Functional Dyspepsia Treatment Using Virtual Reality

for Functional Dyspepsia

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75

Code: NCT05836597·Recruiting

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Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding

for Endometrial Carcinoma

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: Female·Age: 55+

Code: NCT06365905·Recruiting

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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

41 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06297226·Phase 2·Recruiting

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B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies

for B-Cell Non-Hodgkin Lymphoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06191887·Phase 1·Recruiting

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Fasting Mimicking Diet for Reducing Immune Related Adverse Events for Cancer Patients on Immune Checkpoint Inhibitors, FMD-ICI Trial

for Advanced Malignant Solid Neoplasm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06438588·Recruiting

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Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

for Breast Cancer

673 locations incl. Anchorage

Sponsor: NRG Oncology

Sex: All·Age: 18 - 100

Code: NCT05896189·Recruiting

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Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

for Malignant Central Nervous System Neoplasm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06117930·Recruiting

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A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

for Multiple Myeloma

17 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06121843·Phase 1·Recruiting

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A Collaborative Intervention for Improving Cancer Pain Management in Cancer Survivors

for Hematopoietic and Lymphoid System Neoplasm

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06198010·Recruiting

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Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

for Muscle Invasive Bladder Urothelial Carcinoma

490 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05987241·Phase 2, Phase 3·Recruiting

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Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial

for Metastatic Digestive System Neuroendocrine Tumor G1

33 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05773274·Phase 2·Recruiting

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Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple Myeloma

for Recurrent Multiple Myeloma

Drug: Belantamab mafodotin

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05847569·Phase 2·Recruiting

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Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis

for Metastatic Penile Squamous Cell Carcinoma

3 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT06104618·Phase 2·Recruiting

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Neurotization of the Nipple Areolar Complex to Restore Sensation for Patients With Breast Cancer Undergoing Nipple Sparing Mastectomy and Reconstruction

for Anatomic Stage 0 Breast Cancer AJCC v8

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT06153836·Phase 2·Recruiting

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Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma

for Clinical Stage I Esophageal Adenocarcinoma AJCC v8

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06078709·Phase 2·Recruiting

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iCCaRE Consortium Pilot Project 1: Feasibility of a Point of Prostate Cancer Diagnosis Intervention for Newly Diagnosed Black Men

for Prostate Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: Up to 80·Accepts healthy volunteers

Code: NCT06535802·Recruiting

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

1208 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting

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Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

for Barrett Esophagus

5 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT06071845·Recruiting

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Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

for Plasma Cell Myeloma

397 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: All ages

Code: NCT05561387·Phase 3·Recruiting

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INTERogating Cancer for Etiology, Prevention and Therapy Navigation

for Cancer

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06008392·Recruiting

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Vaccine Therapy Plus Pembrolizumab in Treating Advanced Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer

for Fallopian Tube Carcinosarcoma

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05920798·Phase 1, Phase 2·Recruiting

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Testing the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel) and Immunotherapy (Pembrolizumab) for Metastatic Triple-Negative Breast Cancer

for Anatomic Stage III Breast Cancer AJCC v8

10 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05673200·Phase 1·Recruiting

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A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

for Systemic Lupus Erythematosus

31 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT05869955·Phase 1·Recruiting

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At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for Advanced Anal Carcinoma

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05969860·Phase 2·Recruiting

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Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

for Locally Advanced Lung Non-Small Cell Carcinoma

470 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05624996·Phase 3·Recruiting

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Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

for Recurrent Glioblastoma, IDH-Wildtype

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05789394·Phase 1·Recruiting

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

820 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting

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A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

for Advanced Solid Tumor

5 locations incl. Scottsdale

Sponsor: GI Innovation, Inc.

Sex: All·Age: 18+

Code: NCT05824975·Phase 1, Phase 2·Recruiting

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Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial

for Malignant Glioma

2 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05030298·Phase 1·Recruiting

Apply to this trial