Paid Clinical Trials in Irvine, CA

As of June 2026, 386 paid clinical trials are recruiting in Irvine, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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386 clinical trials

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A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

for NonSegmental Vitiligo

Drug: Ruxolitinib

80 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 11

Code: NCT06548360·Phase 3·Recruiting

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Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Nemtabrutinib

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06572618·Phase 2·Recruiting

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A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

for Parkinson Disease

45 locations incl. Sun City

Sponsor: Neuron23 Inc.

Sex: All·Age: 40 - 80

Code: NCT06680830·Phase 2·Recruiting

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A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

for NSCLC (Advanced Non-small Cell Lung Cancer)

23 locations incl. Phoenix

Sponsor: BlossomHill Therapeutics

Sex: All·Age: 18+

Code: NCT06706076·Phase 1, Phase 2·Recruiting

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A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

for Chronic Lymphocytic Leukemia

21 locations incl. Chandler

Sponsor: Loxo Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06588478·Phase 2·Recruiting

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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

for Major Depressive Disorder

46 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT06775379·Phase 3·Recruiting

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Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia

for Recurrent Hairy Cell Leukemia

Drug: Venetoclax

21 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311227·Phase 2·Recruiting

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A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Drug: Amivantamab

150 locations incl. Daphne

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06667076·Phase 2·Recruiting

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A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma

8 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06628310·Phase 2·Recruiting

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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

256 locations incl. Tucson

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting

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Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

for Degenerative Disc Disease

6 locations incl. Irvine

Sponsor: Kuros Biosurgery AG

Sex: All·Age: 18+

Code: NCT04679844·Recruiting

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The Effects of Energy Healing in Fibromyalgia

for Fibromyalgia

1 location in Irvine

Sponsor: University of California, Irvine

Sex: Female·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06552728·Recruiting

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A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

for Hormone Receptor Positive HER-2 Negative Breast Cancer

35 locations incl. Birmingham

Sponsor: Puma Biotechnology, Inc.

Sex: All·Age: 18+

Code: NCT06369285·Phase 2·Recruiting

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Clinical Protocol CERN Feasibility Study

for Bacterial Vaginosis

3 locations incl. Irvine

Sponsor: Cern Corporation

Sex: Female·Age: 18+

Code: NCT06933420·Recruiting

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A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

for Nasopharyngeal Cancer Recurrent

12 locations incl. Little Rock

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 12+

Code: NCT06457503·Phase 4·Recruiting

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Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohn Disease

43 locations incl. Fairhope

Sponsor: Abivax S.A.

Sex: All·Age: 18 - 75

Code: NCT06456593·Phase 2·Recruiting

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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

for Age-related Macular Degeneration (AMD)

Drug: Cemdisiran

152 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT06541704·Phase 3·Recruiting

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Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

for Classic Follicular Lymphoma

Drug: Mosunetuzumab

267 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06337318·Phase 3·Recruiting

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Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

58 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting

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A Phase I Trial of 61Cu-NODAGA-PSMA for Patients with Prostate Cancer

for Prostate Adenocarcinoma

1 location in Irvine

Sponsor: Hoag Memorial Hospital Presbyterian

Sex: Male·Age: 18+

Code: NCT06736054·Phase 1·Recruiting

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A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

for Episodic Migraine

71 locations incl. Birmingham

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT06625060·Phase 2·Recruiting

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Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

for Metastatic Pancreatic Adenocarcinoma

22 locations incl. Arcadia

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06524973·Recruiting

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Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

for Acute Respiratory Distress Syndrome

15 locations incl. Irvine

Sponsor: BioAegis Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05947955·Phase 2·Recruiting

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting

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Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH)

for Hemophagocytic Lymphohistiocytoses

Drug: Ruxolitinib

3 locations incl. Irvine

Sponsor: Jerry Lee, MD, MSc, MPhil

Sex: All·Age: 18+

Code: NCT06160791·Phase 2·Recruiting

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A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

for Breast Cancer

165 locations incl. Daphne

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06492616·Phase 3·Recruiting

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A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT

for Port-wine Birthmarks

5 locations incl. Irvine

Sponsor: Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT05171894·Phase 2·Recruiting

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Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

for Migraine

Drug: Ubrogepant

103 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06417775·Phase 3·Recruiting

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Mosunetuzumab and Polatuzumab Vedotin for the Treatment of Patients With Relapsed or Refractory Grade 1-3a Follicular Lymphoma

for Recurrent Grade 1 Follicular Lymphoma

Drug: Polatuzumab Vedotin

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06453044·Phase 2·Recruiting

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Study With [225Ac]Ac-FL-020 in mCRPC Participants

for Metastatic Castration-resistant Prostate Cancer

5 locations incl. Duarte

Sponsor: Full-Life Technologies GmbH

Sex: Male·Age: 18+

Code: NCT06492122·Phase 1·Recruiting

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Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

for Refractory Differentiated Thyroid Gland Carcinoma

301 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT06475989·Phase 3·Recruiting

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Treating Pulmonary Embolism With Laguna Thrombectomy System (TRUST)

for Pulmonary Embolism

10 locations incl. Irvine

Sponsor: Innova Vascular, Inc.

Sex: All·Age: 18 - 85

Code: NCT06041594·Recruiting

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Testing the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors

for Metastatic Pancreatic Neuroendocrine Tumor

9 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687123·Phase 1·Recruiting

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

266 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting

Apply to this trial

Study of XB010 in Subjects With Solid Tumors

for Locally Advanced or Metastatic Solid Tumors

15 locations incl. Irvine

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06545331·Phase 1·Recruiting

Apply to this trial

The Effects of Core Shamanism in Fibromyalgia

for Fibromyalgia

1 location in Irvine

Sponsor: University of California, Irvine

Sex: Female·Age: 18 - 75

Code: NCT06579261·Recruiting

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A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

for Advanced Solid Tumor

11 locations incl. Irvine

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06147037·Phase 1·Recruiting

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting

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Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06260033·Phase 2·Recruiting

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A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

for Locally Advanced Solid Tumor

17 locations incl. Irvine

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06521554·Phase 1·Recruiting

Apply to this trial